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Preparation of Interconnected Porous Chitosan Scaffolds by Sodium Acetate Particulate Leaching

Authors
 Jin Ik Lim ; Yong-Keun Lee ; Kook-Jin Lim ; Jeon-Soo Shin 
Citation
 Journal of Biomaterials Science. Polymer edition, Vol.22(10) : 1319~1329, 2011 
Journal Title
 Journal of Biomaterials Science. Polymer edition 
ISSN
 0920-5063 
Issue Date
2011
Abstract
For tissue-engineering applications, a 3D porous chitosan scaffold was simply prepared from a mixture of acidic chitosan solution and sodium acetate particles as the porogen by a salt-leaching method. Differences in the porous structure in terms of pore morphology and interconnectivity between the salt-leached chitosan scaffold and phase-separated scaffold as the control were examined by using scanning electron microscopy, protein release and enzymatic degradation tests. A fibroblast (NIH-3T3) cell culture was performed for cell affinity evaluation. The chitosan scaffold prepared by salt-leaching showed good interconnectivity and improved mechanical properties. Furthermore, the chitosan scaffolds showed a high initial cell adhesion after 4 h cell culture and increased cell proliferation than the control. Thus, salt-leached chitosan scaffolds can be used for various tissue-engineering applications
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93538
DOI
10.1163/092050610X504783
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
Yonsei Authors
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Link
 http://www.tandfonline.com/doi/abs/10.1163/092050610X504783
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