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Preparation of Interconnected Porous Chitosan Scaffolds by Sodium Acetate Particulate Leaching

Authors
 Jin Ik Lim  ;  Yong-Keun Lee  ;  Jeon-Soo Shin  ;  Kook-Jin Lim 
Citation
 JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, Vol.22(10) : 1319-1329, 2011 
Journal Title
 JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION 
ISSN
 0920-5063 
Issue Date
2011
MeSH
Animals ; Biocompatible Materials/chemistry ; Cell Adhesion/physiology ; Cell Proliferation/physiology ; Chitosan*/chemistry ; Materials Testing ; Mice ; Microscopy, Electrochemical, Scanning ; NIH 3T3 Cells ; Porosity ; Sodium Acetate/chemistry ; Tissue Engineering ; Tissue Scaffolds*/chemistry
Keywords
CHITOSAN SCAFFOLD ; POROUS STRUCTURE ; SALT-LEACHING ; TISSUE ENGINEERING
Abstract
For tissue-engineering applications, a 3D porous chitosan scaffold was simply prepared from a mixture of acidic chitosan solution and sodium acetate particles as the porogen by a salt-leaching method. Differences in the porous structure in terms of pore morphology and interconnectivity between the salt-leached chitosan scaffold and phase-separated scaffold as the control were examined by using scanning electron microscopy, protein release and enzymatic degradation tests. A fibroblast (NIH-3T3) cell culture was performed for cell affinity evaluation. The chitosan scaffold prepared by salt-leaching showed good interconnectivity and improved mechanical properties. Furthermore, the chitosan scaffolds showed a high initial cell adhesion after 4 h cell culture and increased cell proliferation than the control. Thus, salt-leached chitosan scaffolds can be used for various tissue-engineering applications
Full Text
http://www.tandfonline.com/doi/abs/10.1163/092050610X504783
DOI
10.1163/092050610X504783
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93538
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