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Direct-Current Treatment as a Safe Sterilization Method for Electrospun Biodegradable Polymer

 Hye-Lee Kim  ;  Jeong Hyun Lee  ;  Jong-Chul Park  ;  Seung Jin Lee  ;  Soo Hyun Kim  ;  Dong Wook Han  ;  Jeong Koo Kim  ;  Bong Joo Park  ;  Inho Han  ;  Jungsung Kim  ;  Hak Hee Kim  ;  Mi Hee Lee 
 Tissue Engineering and Regenerative Medicine (조직공학과 재생의학), Vol.8(3) : 320-325, 2011 
Journal Title
 Tissue Engineering and Regenerative Medicine  (조직공학과 재생의학) 
Issue Date
Sterilization is an essential process for biodegradable polymers to be used as biomaterials or tissue engineered- scaffolds. The characteristics of biodegradable scaffolds can change due to decomposition of constituent polymers due to high temperature, pressure, or moisture during sterilization. This study investigated direct–current (DC) treatment as a safe method that can prevent structural change and deformation. Treatment of electrospun poly (lactic-co-glycolic acid) (PLGA) with DC showed a bactericidal effect within 40 sec at 4 V. When DC was applied at 6 V to the electrospun PLGA, the bactericidal effect emerged within 30 sec. The morphology of fibers and molecular weight of PLGA polymer was maintained after DC treatment. In contrast, electrospun PLGA exposed to ethylene oxide showed fiber degradation, and gamma or e-beam irradiation resulted in decreased molecular weight. The demonstrated improvement in chemical and physical stability of biodegradable polymers after DC sterilization may help extend their application.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실)
Yonsei Authors
김학희(Kim, Hak Hee) ; 김혜리(Kim, Hye Lee) ; 박종철(Park, Jong Chul) ; 이미희(Lee, Mi Hee) ; 이정현(Lee, Jeong Hyun) ; 한인호(Han, In Ho)
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