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Direct-Current Treatment as a Safe Sterilization Method for Electrospun Biodegradable Polymer

Authors
 Hye-Lee Kim  ;  Jeong Hyun Lee  ;  Mi Hee Lee  ;  Hak Hee Kim  ;  Jungsung Kim  ;  Inho Han  ;  Bong Joo Park  ;  Jeong Koo Kim  ;  Dong Wook Han  ;  Soo Hyun Kim  ;  Seung Jin Lee  ;  Jong-Chul Park 
Citation
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.8(3) : 320-325, 2011 
Journal Title
TISSUE ENGINEERING AND REGENERATIVE MEDICINE(조직공학과 재생의학)
ISSN
 1738-2696 
Issue Date
2011
Keywords
direct-current ; biodegradable polymer ; poly(lactic-co-glycolic acid) ; sterilization ; electrospinning
Abstract
Sterilization is an essential process for biodegradable polymers to be used as biomaterials or tissue engineered-
scaffolds. The characteristics of biodegradable scaffolds can change due to decomposition of constituent
polymers due to high temperature, pressure, or moisture during sterilization. This study investigated direct–current
(DC) treatment as a safe method that can prevent structural change and deformation. Treatment of electrospun poly
(lactic-co-glycolic acid) (PLGA) with DC showed a bactericidal effect within 40 sec at 4 V. When DC was applied
at 6 V to the electrospun PLGA, the bactericidal effect emerged within 30 sec. The morphology of fibers and molecular
weight of PLGA polymer was maintained after DC treatment. In contrast, electrospun PLGA exposed to ethylene
oxide showed fiber degradation, and gamma or e-beam irradiation resulted in decreased molecular weight. The
demonstrated improvement in chemical and physical stability of biodegradable polymers after DC sterilization may
help extend their application.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Hak Hee(김학희)
Kim, Hye Lee(김혜리)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
Lee, Jeong Hyun(이정현)
Han, In Ho(한인호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93407
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