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Direct-Current Treatment as a Safe Sterilization Method for Electrospun Biodegradable Polymer
DC Field | Value | Language |
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dc.contributor.author | 김학희 | - |
dc.contributor.author | 김혜리 | - |
dc.contributor.author | 박종철 | - |
dc.contributor.author | 이미희 | - |
dc.contributor.author | 이정현 | - |
dc.contributor.author | 한인호 | - |
dc.date.accessioned | 2014-12-20T16:48:12Z | - |
dc.date.available | 2014-12-20T16:48:12Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93407 | - |
dc.description.abstract | Sterilization is an essential process for biodegradable polymers to be used as biomaterials or tissue engineered- scaffolds. The characteristics of biodegradable scaffolds can change due to decomposition of constituent polymers due to high temperature, pressure, or moisture during sterilization. This study investigated direct–current (DC) treatment as a safe method that can prevent structural change and deformation. Treatment of electrospun poly (lactic-co-glycolic acid) (PLGA) with DC showed a bactericidal effect within 40 sec at 4 V. When DC was applied at 6 V to the electrospun PLGA, the bactericidal effect emerged within 30 sec. The morphology of fibers and molecular weight of PLGA polymer was maintained after DC treatment. In contrast, electrospun PLGA exposed to ethylene oxide showed fiber degradation, and gamma or e-beam irradiation resulted in decreased molecular weight. The demonstrated improvement in chemical and physical stability of biodegradable polymers after DC sterilization may help extend their application. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 320~325 | - |
dc.relation.isPartOf | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Direct-Current Treatment as a Safe Sterilization Method for Electrospun Biodegradable Polymer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Medical Research Center (임상의학연구센터) | - |
dc.contributor.googleauthor | Hye-Lee Kim | - |
dc.contributor.googleauthor | Jeong Hyun Lee | - |
dc.contributor.googleauthor | Mi Hee Lee | - |
dc.contributor.googleauthor | Hak Hee Kim | - |
dc.contributor.googleauthor | Jungsung Kim | - |
dc.contributor.googleauthor | Inho Han | - |
dc.contributor.googleauthor | Bong Joo Park | - |
dc.contributor.googleauthor | Jeong Koo Kim | - |
dc.contributor.googleauthor | Dong Wook Han | - |
dc.contributor.googleauthor | Soo Hyun Kim | - |
dc.contributor.googleauthor | Seung Jin Lee | - |
dc.contributor.googleauthor | Jong-Chul Park | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01095 | - |
dc.contributor.localId | A01169 | - |
dc.contributor.localId | A01662 | - |
dc.contributor.localId | A03127 | - |
dc.contributor.localId | A04317 | - |
dc.contributor.localId | A02777 | - |
dc.relation.journalcode | J02734 | - |
dc.identifier.eissn | 2212-5469 | - |
dc.subject.keyword | direct-current | - |
dc.subject.keyword | biodegradable polymer | - |
dc.subject.keyword | poly(lactic-co-glycolic acid) | - |
dc.subject.keyword | sterilization | - |
dc.subject.keyword | electrospinning | - |
dc.contributor.alternativeName | Kim, Hak Hee | - |
dc.contributor.alternativeName | Kim, Hye Lee | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.alternativeName | Lee, Mi Hee | - |
dc.contributor.alternativeName | Lee, Jeong Hyun | - |
dc.contributor.alternativeName | Han, In Ho | - |
dc.contributor.affiliatedAuthor | Kim, Hak Hee | - |
dc.contributor.affiliatedAuthor | Kim, Hye Lee | - |
dc.contributor.affiliatedAuthor | Park, Jong Chul | - |
dc.contributor.affiliatedAuthor | Lee, Jeong Hyun | - |
dc.contributor.affiliatedAuthor | Han, In Ho | - |
dc.contributor.affiliatedAuthor | Lee, Mi Hee | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 320 | - |
dc.citation.endPage | 325 | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.8(3) : 320-325, 2011 | - |
dc.identifier.rimsid | 27639 | - |
dc.type.rims | ART | - |
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