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Association between the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol and Chronic Kidney Disease in Korean Adults: The 2005 Korean National Health and Nutrition Examination Survey

 Kang H.-T.  ;  Shim J.-Y.  ;  Lee Y.-J.  ;  Lee J.-E.  ;  Linton J.A.  ;  Kim J.-K.  ;  Lee H.-R. 
 Kidney & Blood Pressure Research, Vol.34(3) : 173-179, 2011 
Journal Title
 Kidney & Blood Pressure Research 
Issue Date
Adult ; Asian Continental Ancestry Group ; Blood Pressure/physiology ; Cholesterol, HDL/blood* ; Chronic Disease ; Female ; Glomerular Filtration Rate ; Health Surveys ; Humans ; Kidney Diseases/blood* ; Kidney Diseases/epidemiology ; Kidney Diseases/physiopathology ; Kidney Function Tests ; Korea/epidemiology ; Lipoproteins, HDL/blood* ; Male ; Middle Aged ; Nutrition Surveys ; ROC Curve ; Triglycerides/blood*
Chronic kidney disease ; High-density lipoprotein cholesterol ; Modification of Diet in Renal Disease study ; Triglyceride
Background: The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases. The purpose of this study was to examine the association between TG/HDL-C and chronic kidney disease (CKD) in a nationally representative sample of Korean adults. Methods: This cross-sectional study included 5,503 subjects (≧19 years of age) who participated in the 2005 Korean National Health and Nutrition Examination Survey. CKD was defined as an estimated glomerular filtration rate (eGFR) below 60 ml/min/1.73 m2 as calculated by the abbreviated formula from the Modification of Diet in Renal Disease study. Results: The overall prevalence of CKD in our sample was 9.0%. eGFR was negatively correlated with logarithm-transformed TG/HDL-C in Pearson’s correlation. The prevalence of CKD in increasing TG/HDL-C quintiles was 4.4, 6.6, 9.5, 11.9, and 12.8%. In comparison with the lowest quintile of TG/HDL-C (<1.38), the odds ratio (95% confidence interval) for CKD in the highest quintile of TG/HDL-C (≧4.50) was 2.15 (1.38–3.37), after adjustment for multiple covariates (p value for trend = 0.036). Conclusions: TG/HDL-C was independently associated with increased prevalence of CKD in a sample of Korean adults. --------------------------------------------------------------------------------
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hee Taik(강희택)
Kim, Jong Koo(김종구)
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Jung Eun(이정은) ORCID logo https://orcid.org/0000-0003-0917-2872
Lee, Hye Ree(이혜리)
Linton, John A.(인요한) ORCID logo https://orcid.org/0000-0001-8000-3049
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