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MRI findings of pure ductal carcinoma in situ: kinetic characteristics compared according to lesion type and histopathologic factors.

Authors
 Jeong-Ah Kim  ;  Eun Ju Son  ;  Ji Hyun Youk  ;  Eun-Kyung Kim  ;  Min Jung Kim  ;  Jin Young Kwak  ;  Joon Jeong 
Citation
 AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.196(6) : 1450-1456, 2011 
Journal Title
AMERICAN JOURNAL OF ROENTGENOLOGY
ISSN
 0361-803X 
Issue Date
2011
MeSH
Adult ; Aged ; Analysis of Variance ; Carcinoma in Situ/diagnosis* ; Carcinoma in Situ/diagnostic imaging ; Carcinoma in Situ/pathology ; Carcinoma, Ductal, Breast/diagnosis* ; Carcinoma, Ductal, Breast/diagnostic imaging ; Carcinoma, Ductal, Breast/pathology ; Chi-Square Distribution ; Female ; Humans ; Magnetic Resonance Imaging/methods* ; Middle Aged ; Retrospective Studies ; Ultrasonography, Mammary
Keywords
breast neoplasm ; ductal carcinoma in situ ; dynamic MRI ; kinetic characteristics ; MRI
Abstract
OBJECTIVE: The purposes of this study were to analyze the morphologic and kinetic characteristics of pure ductal carcinoma in situ on MR images and to compare the kinetic characteristics according to MRI lesion type, histopathologic factors, and mammographic and sonographic findings.

MATERIALS AND METHODS: Sixty-seven patients with histologically proven pure ductal carcinoma in situ were included in this study. The MRI findings were analyzed according to the BI-RADS MRI lexicon without knowledge of the pathologic findings. The quantitative variables of the kinetic enhancement pattern calculated for each lesion were initial enhancement slope, peak enhancement, time to peak enhancement, and washout ratio. The histopathologic factors of nuclear grade, hormone receptor status, and c-erbB-2 expression status were reviewed. Mammographic and sonographic findings were reviewed independently without knowledge of the MRI findings. Kinetic characteristics were compared according to MRI lesion type, histopathologic factors, and mammographic and sonographic findings.

RESULTS: The dominant morphologic appearance was a nonmass lesion with segmental and clumped or heterogeneous enhancement. The pure ductal carcinoma in situ lesions exhibited variable enhancement patterns consisting of persistent (34.3%), plateau (52.2%), and washout (13.4%) curves. The mean initial enhancement slope (p < 0.005) and time to peak enhancement (p < 0.05) correlated with MRI lesion type, and time to peak enhancement (p < 0.05) correlated with the sonographic findings. No statistically significant correlations were observed between the kinetic characteristics and histopathologic factors or mammographic findings (p > 0.05).

CONCLUSION: Nonmass lesions and plateau curve enhancement were the dominant MRI findings of pure ductal carcinoma in situ. The lesions with mass appearance at MRI had more suspicious kinetic characteristics than did nonmass lesions.
Full Text
http://www.ajronline.org/doi/abs/10.2214/AJR.10.5027
DOI
10.2214/AJR.10.5027
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Min Jung(김민정) ORCID logo https://orcid.org/0000-0003-4949-1237
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Kim, Jeong Ah(김정아) ORCID logo https://orcid.org/0000-0003-4949-4913
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93290
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