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Local kallikrein-kinin system is involved in podocyte apoptosis under diabetic conditions

 Seung-Jae Kwak  ;  Jisun Paeng  ;  Shin-Wook Kang  ;  Dae Suk Han  ;  Tae-Hyun Yoo  ;  Tae Ik Chang  ;  Jung Tak Park  ;  Dong-Ryeol Ryu  ;  Seung Hyeok Han  ;  Dong-Sub Jung  ;  Jin Ji Li  ;  Hye Young Kang  ;  Bo-Young Nam  ;  Sun Ha Lee  ;  Do Hee Kim 
 Apoptosis, Vol.16(5) : 478-490, 2011 
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The kallikrein-kinin system (KKS) serves as the physiologic counterbalance to the renin-angiotensin system. This study was conducted to examine the changes in the expression of KKS components in podocytes under diabetic conditions and to elucidate the functional role of bradykinin (BK) in diabetes-associated podocyte apoptosis. Thirty-two rats were injected with either diluent (n = 16, C) or with streptozotocin intraperitoneally (n = 16, DM), and 8 rats from each group were treated with BK infusion for 6 weeks. Immortalized mouse podocytes were cultured in media containing 5.6 mmol/l glucose (NG), NG + 10(-7) mol/l AII (AII), or 30 mmol/l glucose (HG) with or without 10(-8) mol/l BK. Urinary albumin excretion was significantly higher in DM rats, and this increase was ameliorated by BK. Not only kininogen, kallikrein, and BK B1- and B2-receptor expression but also BK levels were significantly decreased in DM glomeruli and in cultured podocytes exposed to HG. The changes in the expressions of apoptosis-related molecules and the increase in the number of apoptotic cells in DM glomeruli as well as in HG- and AII-stimulated podocytes were significantly abrogated by BK. The suppressed KSS within podocytes under diabetic condition was associated with podocyte apoptosis, suggesting that BK may be beneficial in preventing podocyte loss in diabetic nephropathy.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
강신욱(Kang, Shin Wook) ; 강혜영(Kang, Hye Young) ; 곽승재(Kwak, Seung Jae) ; 김도희(Kim, Do Hee) ; 남보영(Nam, Bo Young) ; 박정탁(Park, Jung Tak) ; 유태현(Yoo, Tae Hyun) ; 장태익(Chang, Tae Ik) ; 정동섭(Jung, Dong Sub) ; 팽지선(Paeng, Ji Sun) ; 한대석(Han, Dae Suk) ; 한승혁(Han, Seung Hyeok)
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