Cited 16 times in
Local kallikrein-kinin system is involved in podocyte apoptosis under diabetic conditions
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 강혜영 | - |
dc.contributor.author | 곽승재 | - |
dc.contributor.author | 김도희 | - |
dc.contributor.author | 남보영 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 장태익 | - |
dc.contributor.author | 정동섭 | - |
dc.contributor.author | 팽지선 | - |
dc.contributor.author | 한대석 | - |
dc.date.accessioned | 2014-12-20T16:44:00Z | - |
dc.date.available | 2014-12-20T16:44:00Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1360-8185 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93274 | - |
dc.description.abstract | The kallikrein-kinin system (KKS) serves as the physiologic counterbalance to the renin-angiotensin system. This study was conducted to examine the changes in the expression of KKS components in podocytes under diabetic conditions and to elucidate the functional role of bradykinin (BK) in diabetes-associated podocyte apoptosis. Thirty-two rats were injected with either diluent (n = 16, C) or with streptozotocin intraperitoneally (n = 16, DM), and 8 rats from each group were treated with BK infusion for 6 weeks. Immortalized mouse podocytes were cultured in media containing 5.6 mmol/l glucose (NG), NG + 10(-7) mol/l AII (AII), or 30 mmol/l glucose (HG) with or without 10(-8) mol/l BK. Urinary albumin excretion was significantly higher in DM rats, and this increase was ameliorated by BK. Not only kininogen, kallikrein, and BK B1- and B2-receptor expression but also BK levels were significantly decreased in DM glomeruli and in cultured podocytes exposed to HG. The changes in the expressions of apoptosis-related molecules and the increase in the number of apoptotic cells in DM glomeruli as well as in HG- and AII-stimulated podocytes were significantly abrogated by BK. The suppressed KSS within podocytes under diabetic condition was associated with podocyte apoptosis, suggesting that BK may be beneficial in preventing podocyte loss in diabetic nephropathy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 478~490 | - |
dc.relation.isPartOf | APOPTOSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis*/drug effects | - |
dc.subject.MESH | Bradykinin/pharmacology | - |
dc.subject.MESH | Bradykinin/physiology* | - |
dc.subject.MESH | Cytoprotection | - |
dc.subject.MESH | Diabetes Mellitus, Experimental/chemically induced | - |
dc.subject.MESH | Diabetes Mellitus, Experimental/metabolism* | - |
dc.subject.MESH | Diabetes Mellitus, Experimental/pathology | - |
dc.subject.MESH | Diabetic Nephropathies/metabolism* | - |
dc.subject.MESH | Diabetic Nephropathies/pathology | - |
dc.subject.MESH | Gene Expression | - |
dc.subject.MESH | Glucose/metabolism | - |
dc.subject.MESH | Kallikrein-Kinin System* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Podocytes/drug effects | - |
dc.subject.MESH | Podocytes/metabolism* | - |
dc.subject.MESH | Podocytes/pathology | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.title | Local kallikrein-kinin system is involved in podocyte apoptosis under diabetic conditions | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Seung-Jae Kwak | - |
dc.contributor.googleauthor | Jisun Paeng | - |
dc.contributor.googleauthor | Do Hee Kim | - |
dc.contributor.googleauthor | Sun Ha Lee | - |
dc.contributor.googleauthor | Bo-Young Nam | - |
dc.contributor.googleauthor | Hye Young Kang | - |
dc.contributor.googleauthor | Jin Ji Li | - |
dc.contributor.googleauthor | Dong-Sub Jung | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Dong-Ryeol Ryu | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Tae Ik Chang | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Dae Suk Han | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.identifier.doi | 10.1007/s10495-011-0585-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04304 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A00096 | - |
dc.contributor.localId | A00170 | - |
dc.contributor.localId | A01251 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A03486 | - |
dc.contributor.localId | A03594 | - |
dc.contributor.localId | A04241 | - |
dc.contributor.localId | A04272 | - |
dc.contributor.localId | A00395 | - |
dc.relation.journalcode | J00195 | - |
dc.identifier.eissn | 1573-675X | - |
dc.identifier.pmid | 21373934 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10495-011-0585-1 | - |
dc.subject.keyword | Diabetic nephropathy | - |
dc.subject.keyword | Kallikrein–kinin system | - |
dc.subject.keyword | p38 MAPK | - |
dc.subject.keyword | Podocyte | - |
dc.subject.keyword | Apoptosis | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.alternativeName | Kang, Hye Young | - |
dc.contributor.alternativeName | Kwak, Seung Jae | - |
dc.contributor.alternativeName | Kim, Do Hee | - |
dc.contributor.alternativeName | Nam, Bo Young | - |
dc.contributor.alternativeName | Park, Jung Tak | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Chang, Tae Ik | - |
dc.contributor.alternativeName | Jung, Dong Sub | - |
dc.contributor.alternativeName | Paeng, Ji Sun | - |
dc.contributor.alternativeName | Han, Dae Suk | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Kang, Hye Young | - |
dc.contributor.affiliatedAuthor | Kwak, Seung Jae | - |
dc.contributor.affiliatedAuthor | Nam, Bo Young | - |
dc.contributor.affiliatedAuthor | Park, Jung Tak | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Chang, Tae Ik | - |
dc.contributor.affiliatedAuthor | Jung, Dong Sub | - |
dc.contributor.affiliatedAuthor | Paeng, Ji Sun | - |
dc.contributor.affiliatedAuthor | Han, Dae Suk | - |
dc.contributor.affiliatedAuthor | Kim, Do Hee | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 16 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 478 | - |
dc.citation.endPage | 490 | - |
dc.identifier.bibliographicCitation | APOPTOSIS, Vol.16(5) : 478-490, 2011 | - |
dc.identifier.rimsid | 27106 | - |
dc.type.rims | ART | - |
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