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Sex differences in the relationship between leukocyte count and chronic kidney disease: the 2007 Korean National Health and Nutrition Examination Survey

Authors
 Ha-Young Na ; Jae-Yong Shim ; Yong-Jae Lee ; Rae-Jun Jung ; Byoung-Jin Park ; Hong-Bae Kim ; Dong-Hyuk Jung ; Hye-Ree Lee 
Citation
 Journal of Womens Health, Vol.20(1) : 99~105, 2011 
Journal Title
 Journal of Womens Health 
ISSN
 1540-9996 
Issue Date
2011
Abstract
BACKGROUND: Chronic kidney disease (CKD) has emerged as an independent predictor for cardiovascular disease (CVD), which is now regarded as an inflammatory disease. This study aimed to determine the association of CKD with white blood cell (WBC) count as a marker of systemic inflammation. METHODS: We examined the association of WBC count with CKD in 2825 Korean adults (1155 men, 1670 women) in the 2007 Korean National Health and Nutrition Examination Survey (KNHANES). CKD was defined as either proteinuria or a glomerular filtration rate (GFR) <60 mL/min/1.73 m(2). The odds ratios (ORs) for CKD were calculated using multivariate logistic regression analysis after adjusting for confounding variables across gender-specific WBC count quartiles. RESULTS: The proportion of CKD increased with increasing WBC quartiles, from 9.7% in the lowest quartile to 20.7% in the highest quartile for women. In multivariate logistic regression analysis, the corresponding odds ratios (95% confidence intervals [CIs]) for a CKD across WBC count quartiles among women were 1.00, 1.45 (0.91-2.31), 1.65 (1.03-2.63), and 2.11 (1.33-3.35), after adjusting for age, body mass index (BMI), systolic blood pressure, fasting plasma glucose, smoking status, current drinking high-density lipoprotein cholesterol (HDL-C), and triglyceride. In contrast, compared with women, men appeared to have no significant results of a relationship between WBC quartiles and CKD. CONCLUSIONS: Our study shows a significant association between WBC count and the risk for CKD in women. Accordingly, potential health benefits of early detection of a higher level of WBC count may be useful for CKD risk assessment in women.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93114
DOI
10.1089/jwh.2010.2115
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Family Medicine
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Link
 http://online.liebertpub.com/doi/abs/10.1089/jwh.2010.2115
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