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Sex differences in the relationship between leukocyte count and chronic kidney disease: the 2007 Korean National Health and Nutrition Examination Survey

 Ha-Young Na  ;  Jae-Yong Shim  ;  Hye-Ree Lee  ;  Dong-Hyuk Jung  ;  Hong-Bae Kim  ;  Byoung-Jin Park  ;  Rae-Jun Jung  ;  Yong-Jae Lee 
 JOURNAL OF WOMENS HEALTH, Vol.20(1) : 99-105, 2011 
Journal Title
Issue Date
Adult ; Alcohol Drinking/epidemiology ; Alcohol Drinking/psychology ; Biomarkers ; Blood Pressure/physiology ; Body Mass Index ; Cholesterol/blood ; Cross-Sectional Studies ; Female ; Glomerular Filtration Rate/physiology ; Health Knowledge, Attitudes, Practice* ; Humans ; Korea/epidemiology ; Leukocyte Count* ; Logistic Models ; Male ; Middle Aged ; National Health Programs ; Nutrition Surveys ; Proteinuria/physiopathology ; Renal Insufficiency, Chronic/epidemiology* ; Smoking/epidemiology ; Smoking/psychology ; Surveys and Questionnaires
BACKGROUND: Chronic kidney disease (CKD) has emerged as an independent predictor for cardiovascular disease (CVD), which is now regarded as an inflammatory disease. This study aimed to determine the association of CKD with white blood cell (WBC) count as a marker of systemic inflammation.

METHODS: We examined the association of WBC count with CKD in 2825 Korean adults (1155 men, 1670 women) in the 2007 Korean National Health and Nutrition Examination Survey (KNHANES). CKD was defined as either proteinuria or a glomerular filtration rate (GFR) <60 mL/min/1.73 m(2). The odds ratios (ORs) for CKD were calculated using multivariate logistic regression analysis after adjusting for confounding variables across gender-specific WBC count quartiles.

RESULTS: The proportion of CKD increased with increasing WBC quartiles, from 9.7% in the lowest quartile to 20.7% in the highest quartile for women. In multivariate logistic regression analysis, the corresponding odds ratios (95% confidence intervals [CIs]) for a CKD across WBC count quartiles among women were 1.00, 1.45 (0.91-2.31), 1.65 (1.03-2.63), and 2.11 (1.33-3.35), after adjusting for age, body mass index (BMI), systolic blood pressure, fasting plasma glucose, smoking status, current drinking high-density lipoprotein cholesterol (HDL-C), and triglyceride. In contrast, compared with women, men appeared to have no significant results of a relationship between WBC quartiles and CKD.

CONCLUSIONS: Our study shows a significant association between WBC count and the risk for CKD in women. Accordingly, potential health benefits of early detection of a higher level of WBC count may be useful for CKD risk assessment in women.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Na, Ha Young(나하영)
Park, Byoungjin(박병진) ORCID logo https://orcid.org/0000-0003-1733-5301
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Ree(이혜리)
Jung, Dong Hyuk(정동혁) ORCID logo https://orcid.org/0000-0002-3411-0676
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