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Contribution of computed tomography to ultrasound in predicting lateral lymph node metastasis in patients with papillary thyroid carcinoma

Authors
 Jung Hyun Yoon  ;  Ji Youn Kim  ;  Hee Jung Moon  ;  Ji Hyun Youk  ;  Eun Joo Son  ;  Eun-Kyung Kim  ;  Kyung Hwa Han  ;  Jin Young Kwak 
Citation
 ANNALS OF SURGICAL ONCOLOGY, Vol.18(6) : 1734-1741, 2011 
Journal Title
ANNALS OF SURGICAL ONCOLOGY
ISSN
 1068-9265 
Issue Date
2011
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy, Fine-Needle ; Carcinoma, Papillary/diagnostic imaging* ; Carcinoma, Papillary/secondary ; Female ; Humans ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology* ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Sensitivity and Specificity ; Thyroid Neoplasms/diagnostic imaging* ; Thyroid Neoplasms/pathology ; Tomography, X-Ray Computed ; Ultrasonography ; Young Adult
Keywords
Thyroid Cancer ; Papillary Thyroid Carcinoma ; Diagnostic Performance ; Metastatic Lymph Node ; Cervical Lymph Node
Abstract
BACKGROUND: To evaluate the most accurate criteria using ultrasound (US) and contrast-enhanced computed tomography (CT) in predicting lateral lymph node metastasis in patients with papillary thyroid carcinoma (PTC).

METHODS: A total of 122 lateral cervical lymph nodes of 113 patients diagnosed with PTC underwent preoperative US-guided fine-needle aspiration biopsy (US-FNAB) and CT. Degree of enhancement (DOE) was calculated by the differences of Hounsfield units (HU) between the lymph node and the ipsilateral sternocleiomastoideus muscle. Standard reference was set by surgical pathology results. Diagnostic performances of US, CT, and cutoff value for DOE were analyzed.

RESULTS: Seventy lymph nodes (57.4%) were metastases, and 52 (42.6%) were benign. The cutoff value of DOE on CT was 35.7 HU. Diagnostic performance of CT including DOE of 35.7 HU was lower than US, but without significance (P = 0.321). When any suspicious CT feature was combined with the combination of suspicious US features, values of the area under the receiver operating characteristic curve decreased compared to the combinations of suspicious US features alone, 0.785 to 0.741, respectively (P = 0.225).

CONCLUSIONS: Contrast-enhanced CT does not greatly improve diagnostic values of US in the diagnosis of metastatic lateral cervical lymph nodes in patients with PTC.
Full Text
http://link.springer.com/article/10.1245%2Fs10434-010-1527-9
DOI
10.1245/s10434-010-1527-9
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Kim, Ji Youn(김지연)
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
Han, Kyung Hwa(한경화)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93041
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