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Prognostic factors and 10-year survival in patients with hepatocellular carcinoma after curative hepatectomy

Authors
 Sung Hoon Kim ; Sae Byeol Choi ; Kyung Sik Kim ; Jin Sub Choi ; Do Young Kim ; Mi-Suk Park ; Seung Up Kim ; Jae Gil Lee 
Citation
 Journal of Gastrointestinal Surgery, Vol.15(4) : 598~607, 2011 
Journal Title
 Journal of Gastrointestinal Surgery 
ISSN
 1091-255X 
Issue Date
2011
Abstract
PURPOSE: There were contrary results about the effects of hepatitis B e antigen (HBeAg) positivity on the long-term survival in patients with hepatocellular carcinoma (HCC) after curative resection. PATIENTS AND METHODS: Medical records of 170 HCC patients who underwent curative liver resections were retrospectively reviewed. The 10-year survival rate and correlations among clinical, laboratory, and pathological data, especially HBeAg, were analyzed. RESULTS: Fifty-two patients survived more than 10 years. The 10-year actual overall survival (OS) rate was 30.6%, and the actual disease-free survival (DFS) rate was 24.1%. The median OS and DFS were 76 and 35 months, respectively. In multivariate analysis, HBeAg positivity (P = 0.032; hazard ratio [HR], 3.041), presence of a satellite nodule (P = 0.007; HR, 4.166), and elevated ICG R15 (P = 0.003; HR, 4.915) had a significant negative correlation with the 10-year DFS rate. In addition, HBeAg positivity (P = 0.044; HR, 3.725) and recurrence (recur within 1 year, P < 0.001; HR, 41.296; recur after 1 year, P = 0.03; HR, 4.848) were found as independent factors which were negatively correlated to the 10-year OS. CONCLUSIONS: The presence of HBeAg was significantly correlated to DFS and OS after curative resection for HCC. Active treatment of B viral hepatitis before and after surgery should be provided to prolong survival in patients with 5-10-cm HCC.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92929
DOI
10.1007/s11605-011-1452-7
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs11605-011-1452-7
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