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Prognostic factors and 10-year survival in patients with hepatocellular carcinoma after curative hepatectomy

Authors
 Sung Hoon Kim  ;  Sae Byeol Choi  ;  Jae Gil Lee  ;  Seung Up Kim  ;  Mi-Suk Park  ;  Do Young Kim  ;  Jin Sub Choi  ;  Kyung Sik Kim 
Citation
 JOURNAL OF GASTROINTESTINAL SURGERY, Vol.15(4) : 598-607, 2011 
Journal Title
JOURNAL OF GASTROINTESTINAL SURGERY
ISSN
 1091-255X 
Issue Date
2011
MeSH
Adolescent ; Adult ; Aged ; Carcinoma, Hepatocellular/mortality* ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/secondary ; Carcinoma, Hepatocellular/surgery ; Disease-Free Survival ; Female ; Hepatectomy* ; Hepatitis B e Antigens/blood ; Humans ; Liver Neoplasms/mortality* ; Liver Neoplasms/pathology ; Liver Neoplasms/surgery ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; Prognosis ; Survival Rate ; Young Adult
Keywords
HBeAg ; Tumor size ; Hepatocellular carcinoma ; 10-Year survival
Abstract
PURPOSE: There were contrary results about the effects of hepatitis B e antigen (HBeAg) positivity on the long-term survival in patients with hepatocellular carcinoma (HCC) after curative resection.

PATIENTS AND METHODS: Medical records of 170 HCC patients who underwent curative liver resections were retrospectively reviewed. The 10-year survival rate and correlations among clinical, laboratory, and pathological data, especially HBeAg, were analyzed.

RESULTS: Fifty-two patients survived more than 10 years. The 10-year actual overall survival (OS) rate was 30.6%, and the actual disease-free survival (DFS) rate was 24.1%. The median OS and DFS were 76 and 35 months, respectively. In multivariate analysis, HBeAg positivity (P = 0.032; hazard ratio [HR], 3.041), presence of a satellite nodule (P = 0.007; HR, 4.166), and elevated ICG R15 (P = 0.003; HR, 4.915) had a significant negative correlation with the 10-year DFS rate. In addition, HBeAg positivity (P = 0.044; HR, 3.725) and recurrence (recur within 1 year, P < 0.001; HR, 41.296; recur after 1 year, P = 0.03; HR, 4.848) were found as independent factors which were negatively correlated to the 10-year OS.

CONCLUSIONS: The presence of HBeAg was significantly correlated to DFS and OS after curative resection for HCC. Active treatment of B viral hepatitis before and after surgery should be provided to prolong survival in patients with 5-10-cm HCC.
Full Text
http://link.springer.com/article/10.1007%2Fs11605-011-1452-7
DOI
10.1007/s11605-011-1452-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Do Young(김도영)
Kim, Sung Hoon(김성훈)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Lee, Jae Gil(이재길) ORCID logo https://orcid.org/0000-0002-1148-8035
Choi, Jin Sub(최진섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92929
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