Cited 31 times in
Prognostic factors and 10-year survival in patients with hepatocellular carcinoma after curative hepatectomy
DC Field | Value | Language |
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dc.contributor.author | 김경식 | - |
dc.contributor.author | 김도영 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김승업 | - |
dc.contributor.author | 박미숙 | - |
dc.contributor.author | 이재길 | - |
dc.contributor.author | 최진섭 | - |
dc.date.accessioned | 2014-12-20T16:33:00Z | - |
dc.date.available | 2014-12-20T16:33:00Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1091-255X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92929 | - |
dc.description.abstract | PURPOSE: There were contrary results about the effects of hepatitis B e antigen (HBeAg) positivity on the long-term survival in patients with hepatocellular carcinoma (HCC) after curative resection. PATIENTS AND METHODS: Medical records of 170 HCC patients who underwent curative liver resections were retrospectively reviewed. The 10-year survival rate and correlations among clinical, laboratory, and pathological data, especially HBeAg, were analyzed. RESULTS: Fifty-two patients survived more than 10 years. The 10-year actual overall survival (OS) rate was 30.6%, and the actual disease-free survival (DFS) rate was 24.1%. The median OS and DFS were 76 and 35 months, respectively. In multivariate analysis, HBeAg positivity (P = 0.032; hazard ratio [HR], 3.041), presence of a satellite nodule (P = 0.007; HR, 4.166), and elevated ICG R15 (P = 0.003; HR, 4.915) had a significant negative correlation with the 10-year DFS rate. In addition, HBeAg positivity (P = 0.044; HR, 3.725) and recurrence (recur within 1 year, P < 0.001; HR, 41.296; recur after 1 year, P = 0.03; HR, 4.848) were found as independent factors which were negatively correlated to the 10-year OS. CONCLUSIONS: The presence of HBeAg was significantly correlated to DFS and OS after curative resection for HCC. Active treatment of B viral hepatitis before and after surgery should be provided to prolong survival in patients with 5-10-cm HCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 598~607 | - |
dc.relation.isPartOf | JOURNAL OF GASTROINTESTINAL SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Hepatocellular/mortality* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology | - |
dc.subject.MESH | Carcinoma, Hepatocellular/secondary | - |
dc.subject.MESH | Carcinoma, Hepatocellular/surgery | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hepatectomy* | - |
dc.subject.MESH | Hepatitis B e Antigens/blood | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/mortality* | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Liver Neoplasms/surgery | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Young Adult | - |
dc.title | Prognostic factors and 10-year survival in patients with hepatocellular carcinoma after curative hepatectomy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Sung Hoon Kim | - |
dc.contributor.googleauthor | Sae Byeol Choi | - |
dc.contributor.googleauthor | Jae Gil Lee | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.contributor.googleauthor | Mi-Suk Park | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Jin Sub Choi | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.identifier.doi | 10.1007/s11605-011-1452-7 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A01463 | - |
dc.contributor.localId | A03070 | - |
dc.contributor.localId | A04199 | - |
dc.contributor.localId | A00597 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J01418 | - |
dc.identifier.eissn | 1873-4626 | - |
dc.identifier.pmid | 21336497 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs11605-011-1452-7 | - |
dc.subject.keyword | HBeAg | - |
dc.subject.keyword | Tumor size | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | 10-Year survival | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.alternativeName | Park, Mi Sook | - |
dc.contributor.alternativeName | Lee, Jae Gil | - |
dc.contributor.alternativeName | Choi, Jin Sub | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | Park, Mi-Suk | - |
dc.contributor.affiliatedAuthor | Lee, Jae Gil | - |
dc.contributor.affiliatedAuthor | Choi, Jin Sub | - |
dc.contributor.affiliatedAuthor | Kim, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 15 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 598 | - |
dc.citation.endPage | 607 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROINTESTINAL SURGERY, Vol.15(4) : 598-607, 2011 | - |
dc.identifier.rimsid | 27909 | - |
dc.type.rims | ART | - |
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