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Relationship of neutrophil-lymphocyte ratio with arterial stiffness and coronary calcium score

 Byoung-Jin Park  ;  Jae-Yong Shim  ;  Hye-Ree Lee  ;  Jung-Hyun Lee  ;  Dong-Hyuk Jung  ;  Hong-Bae Kim  ;  Ha-Young Na  ;  Yong-Jae Lee 
 Clinica Chimica Acta, Vol.412(11-12) : 925-929, 2011 
Journal Title
 Clinica Chimica Acta 
Issue Date
BACKGROUND: Emerging evidence suggests that the neutrophil/lymphocyte ratio (NLR) may be a useful marker of cardiovascular disease and a more powerful predictor than any other leukocyte subtypes. We determined whether NLR is related to atherosclerosis measured by brachial-ankle pulse wave velocity (baPWV) and coronary calcium score (CCS). METHODS: We examined the relationship of NLR with baPWV and CCS in 849 Korean adults in a health examination program. The odds ratios for a high baPWV or a high CCS were calculated using multivariate logistic regression analysis across NLR quartiles. A high baPWV was defined as >1500 cm/s (>75th percentile) and a high CCS was defined as over 100 (at least moderate atherosclerotic plaque burden). RESULTS: The ORs (95% CIs) for a high baPWV by NLR quartiles were 1.00, 0.76 (0.41-1.39), 1.08 (0.61-1.90), and 2.12 (1.18-3.83) after adjusting for confounding variables. Similarly, positive associations between NLR and a high CCS were also observed after adjusting for the same co-variables. CONCLUSION: A higher NLR was independently associated with arterial stiffness and CCS. Accordingly, a higher NLR may be a useful additional measure in assessing cardiovascular risks in clinical practice.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)
Yonsei Authors
나하영(Na, Ha Young)
박병진(Park, Byoung Jin) ORCID logo https://orcid.org/0000-0003-1733-5301
심재용(Shim, Jae Yong) ORCID logo https://orcid.org/0000-0002-9561-9230
이용제(Lee, Yong Jae) ORCID logo https://orcid.org/0000-0002-6697-476X
이혜리(Lee, Hye Ree)
정동혁(Jung, Dong Hyuk) ORCID logo https://orcid.org/0000-0002-3411-0676
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