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Binary mixing of micelles using Pluronics for a nano-sized drug delivery system

Authors
 Eun Seong Lee  ;  Young Taik Oh  ;  Yu Seok Youn  ;  Myounghwa Nam  ;  Byungtae Park  ;  Jungmin Yun  ;  Ji Hoon Kim  ;  Ho-Taek Song  ;  Kyung Taek Oh 
Citation
 COLLOIDS AND SURFACES B-BIOINTERFACES, Vol.82(1) : 190-195, 2011 
Journal Title
 COLLOIDS AND SURFACES B-BIOINTERFACES 
ISSN
 0927-7765 
Issue Date
2011
MeSH
Azo Compounds/chemistry ; Drug Delivery Systems* ; Fluorescence ; Micelles* ; Nanoparticles/chemistry* ; Nephelometry and Turbidimetry ; Particle Size* ; Poloxamer/chemistry* ; Solubility ; Solutions ; Spectrum Analysis
Keywords
Pluronic ; Nano-sized ; Drug delivery system ; Solubilization capacity ; Binary system
Abstract
Pluronics with different structural compositions and properties are used for several applications, including drug delivery systems. We developed a binary mixing system with two Pluronics, L121/P123, as a nano-sized drug delivery carrier. The lamellar-forming Pluronic L121 (0.1 wt%) was incorporated with Pluronic P123 to produce nano-sized dispersions (in case of 0.1 and 0.5 wt% P123) with high stability due to Pluronic P123 and high solubilization capacity due to Pluronic L121. The binary systems were spherical and less than 200-nm diameter, with high thermodynamic stability (at least 2 weeks) in aqueous solution. The CMC of the binary system was located in the middle of the CMC of each polymer. In particular, the solubilization capacity of the binary system (0.1/0.1 wt%) was higher than mono-systems of P123. The main advantage of binary systems is overcoming limitations of mono systems to allow tailored mixing of block copolymers with different physicochemical characteristics. These nano-sized systems may have potential as anticancer drug delivery systems with simple preparation method, high stability, and high loading capacity.
Full Text
http://www.sciencedirect.com/science/article/pii/S0927776510004911
DOI
10.1016/j.colsurfb.2010.08.033
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92704
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