Cited 107 times in
Binary mixing of micelles using Pluronics for a nano-sized drug delivery system
DC Field | Value | Language |
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dc.contributor.author | 오영택 | - |
dc.contributor.author | 송호택 | - |
dc.date.accessioned | 2014-12-20T16:25:56Z | - |
dc.date.available | 2014-12-20T16:25:56Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92704 | - |
dc.description.abstract | Pluronics with different structural compositions and properties are used for several applications, including drug delivery systems. We developed a binary mixing system with two Pluronics, L121/P123, as a nano-sized drug delivery carrier. The lamellar-forming Pluronic L121 (0.1 wt%) was incorporated with Pluronic P123 to produce nano-sized dispersions (in case of 0.1 and 0.5 wt% P123) with high stability due to Pluronic P123 and high solubilization capacity due to Pluronic L121. The binary systems were spherical and less than 200-nm diameter, with high thermodynamic stability (at least 2 weeks) in aqueous solution. The CMC of the binary system was located in the middle of the CMC of each polymer. In particular, the solubilization capacity of the binary system (0.1/0.1 wt%) was higher than mono-systems of P123. The main advantage of binary systems is overcoming limitations of mono systems to allow tailored mixing of block copolymers with different physicochemical characteristics. These nano-sized systems may have potential as anticancer drug delivery systems with simple preparation method, high stability, and high loading capacity. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 190~195 | - |
dc.relation.isPartOf | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Azo Compounds/chemistry | - |
dc.subject.MESH | DrugDeliverySystems* | - |
dc.subject.MESH | Fluorescence | - |
dc.subject.MESH | Micelles* | - |
dc.subject.MESH | Nanoparticles/chemistry* | - |
dc.subject.MESH | Nephelometry and Turbidimetry | - |
dc.subject.MESH | Particle Size* | - |
dc.subject.MESH | Poloxamer/chemistry* | - |
dc.subject.MESH | Solubility | - |
dc.subject.MESH | Solutions | - |
dc.subject.MESH | Spectrum Analysis | - |
dc.title | Binary mixing of micelles using Pluronics for a nano-sized drug delivery system | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Eun Seong Lee | - |
dc.contributor.googleauthor | Young Taik Oh | - |
dc.contributor.googleauthor | Yu Seok Youn | - |
dc.contributor.googleauthor | Myounghwa Nam | - |
dc.contributor.googleauthor | Byungtae Park | - |
dc.contributor.googleauthor | Jungmin Yun | - |
dc.contributor.googleauthor | Ji Hoon Kim | - |
dc.contributor.googleauthor | Ho-Taek Song | - |
dc.contributor.googleauthor | Kyung Taek Oh | - |
dc.identifier.doi | 10.1016/j.colsurfb.2010.08.033 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02390 | - |
dc.contributor.localId | A02080 | - |
dc.relation.journalcode | J00627 | - |
dc.identifier.eissn | 1873-4367 | - |
dc.identifier.pmid | 20850281 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0927776510004911 | - |
dc.subject.keyword | Pluronic | - |
dc.subject.keyword | Nano-sized | - |
dc.subject.keyword | Drug delivery system | - |
dc.subject.keyword | Solubilization capacity | - |
dc.subject.keyword | Binary system | - |
dc.contributor.alternativeName | Oh, Young Taik | - |
dc.contributor.alternativeName | Song, Ho Taek | - |
dc.contributor.affiliatedAuthor | Oh, Young Taik | - |
dc.contributor.affiliatedAuthor | Song, Ho Taek | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 82 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 190 | - |
dc.citation.endPage | 195 | - |
dc.identifier.bibliographicCitation | COLLOIDS AND SURFACES B-BIOINTERFACES, Vol.82(1) : 190-195, 2011 | - |
dc.identifier.rimsid | 28707 | - |
dc.type.rims | ART | - |
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