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Diagnostic value of BRAF(V600E) mutation analysis of thyroid nodules according to ultrasonographic features and the time of aspiration.

 Hee Jung Moon  ;  Eun-Kyung Kim  ;  Woong Youn Chung  ;  Jong Rak Choi  ;  Jung Hyun Yoon  ;  Jin Young Kwak 
 ANNALS OF SURGICAL ONCOLOGY, Vol.18(3) : 792-799, 2011 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy, Fine-Needle ; Carcinoma, Papillary/diagnostic imaging ; Carcinoma, Papillary/genetics* ; Carcinoma, Papillary/pathology ; DNA Mutational Analysis ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Mutation/genetics* ; Prognosis ; Proto-Oncogene Proteins B-raf/genetics* ; Retrospective Studies ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/genetics* ; Thyroid Neoplasms/pathology ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/genetics* ; Thyroid Nodule/pathology ; Time Factors ; Ultrasonography ; Young Adult
Papillary Thyroid Carcinoma ; Thyroid Nodule ; Benign Nodule BRAFV600E Mutation ; Indeterminate Result
BACKGROUND: We investigated the diagnostic value of the BRAF(V600E) mutation of thyroid nodules according to ultrasonography (US) features and the time of BRAF(V600E) mutation analysis. METHODS: A total of 304 nodules in 295 patients (mean age, 49.4 years) were included. Thyroid nodules were classified as suspicious or probably benign on US. Group 1 (n = 168) included nodules with BRAF(V600E) mutation analysis at the time of the initial US-guided fine needle aspiration biopsy (US-FNAB) and group 2 (n = 136) included nodules with analysis at the time of the repeat US-FNAB. The frequency of malignancy and the BRAF(V600E) mutation were compared between suspicious and probably benign nodules on US and between groups 1 and 2. RESULTS: Of 304 nodules, 113 were malignant and 59 (52.2%) had the BRAF(V600E) mutation. Also, 58 of 196 nodules suspicious on US (29.6%) had the BRAF(V600E) mutation, whereas 1 of 108 (0.9%) probably benign nodules had the BRAF(V600E) mutation (P value <.0001). The BRAF(V600E) mutation was more frequently found in nodules suspicious on US than those probably benign in both groups 1 and 2 (P value <.0001 and .0058, respectively). Preoperative detection of the BRAF(V600E) mutation led surgeons to perform surgery in 5.8% of 103 nodules with benign and nondiagnostic results on cytology in group 1 and 1% of 98 nodules in group 2 without treatment delay. CONCLUSIONS: The BRAF(V600E) mutation analysis was a useful adjunctive diagnostic tool, especially in nodules suspicious on US, and was more effective if performed at the time of the initial US-FNAB.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
Chung, Woung Youn(정웅윤)
Choi, Jong Rak(최종락) ORCID logo https://orcid.org/0000-0002-0608-2989
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