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Diagnostic value of BRAF(V600E) mutation analysis of thyroid nodules according to ultrasonographic features and the time of aspiration.

DC Field Value Language
dc.contributor.author곽진영-
dc.contributor.author김은경-
dc.contributor.author문희정-
dc.contributor.author윤정현-
dc.contributor.author정웅윤-
dc.contributor.author최종락-
dc.date.accessioned2014-12-20T16:23:58Z-
dc.date.available2014-12-20T16:23:58Z-
dc.date.issued2011-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92642-
dc.description.abstractBACKGROUND: We investigated the diagnostic value of the BRAF(V600E) mutation of thyroid nodules according to ultrasonography (US) features and the time of BRAF(V600E) mutation analysis. METHODS: A total of 304 nodules in 295 patients (mean age, 49.4 years) were included. Thyroid nodules were classified as suspicious or probably benign on US. Group 1 (n = 168) included nodules with BRAF(V600E) mutation analysis at the time of the initial US-guided fine needle aspiration biopsy (US-FNAB) and group 2 (n = 136) included nodules with analysis at the time of the repeat US-FNAB. The frequency of malignancy and the BRAF(V600E) mutation were compared between suspicious and probably benign nodules on US and between groups 1 and 2. RESULTS: Of 304 nodules, 113 were malignant and 59 (52.2%) had the BRAF(V600E) mutation. Also, 58 of 196 nodules suspicious on US (29.6%) had the BRAF(V600E) mutation, whereas 1 of 108 (0.9%) probably benign nodules had the BRAF(V600E) mutation (P value <.0001). The BRAF(V600E) mutation was more frequently found in nodules suspicious on US than those probably benign in both groups 1 and 2 (P value <.0001 and .0058, respectively). Preoperative detection of the BRAF(V600E) mutation led surgeons to perform surgery in 5.8% of 103 nodules with benign and nondiagnostic results on cytology in group 1 and 1% of 98 nodules in group 2 without treatment delay. CONCLUSIONS: The BRAF(V600E) mutation analysis was a useful adjunctive diagnostic tool, especially in nodules suspicious on US, and was more effective if performed at the time of the initial US-FNAB.-
dc.description.statementOfResponsibilityopen-
dc.format.extent792~799-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBiopsy, Fine-Needle-
dc.subject.MESHCarcinoma, Papillary/diagnosticimaging-
dc.subject.MESHCarcinoma, Papillary/genetics*-
dc.subject.MESHCarcinoma, Papillary/pathology-
dc.subject.MESHDNA MutationalAnalysis-
dc.subject.MESHDiagnosis, Differential-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMutation/genetics*-
dc.subject.MESHPrognosis-
dc.subject.MESHProto-Oncogene Proteins B-raf/genetics*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHThyroidNeoplasms/diagnosticimaging-
dc.subject.MESHThyroidNeoplasms/genetics*-
dc.subject.MESHThyroidNeoplasms/pathology-
dc.subject.MESHThyroidNodule/diagnosticimaging-
dc.subject.MESHThyroidNodule/genetics*-
dc.subject.MESHThyroidNodule/pathology-
dc.subject.MESHTimeFactors-
dc.subject.MESHUltrasonography-
dc.subject.MESHYoung Adult-
dc.titleDiagnostic value of BRAF(V600E) mutation analysis of thyroid nodules according to ultrasonographic features and the time of aspiration.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorHee Jung Moon-
dc.contributor.googleauthorEun-Kyung Kim-
dc.contributor.googleauthorWoong Youn Chung-
dc.contributor.googleauthorJong Rak Choi-
dc.contributor.googleauthorJung Hyun Yoon-
dc.contributor.googleauthorJin Young Kwak-
dc.identifier.doi10.1245/s10434-010-1354-z-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00182-
dc.contributor.localIdA00801-
dc.contributor.localIdA01397-
dc.contributor.localIdA02595-
dc.contributor.localIdA03674-
dc.contributor.localIdA04182-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid20945104-
dc.identifier.urlhttp://link.springer.com/article/10.1245%2Fs10434-010-1354-z-
dc.subject.keywordPapillary Thyroid Carcinoma-
dc.subject.keywordThyroid Nodule-
dc.subject.keywordBenign Nodule BRAFV600E Mutation-
dc.subject.keywordIndeterminate Result-
dc.contributor.alternativeNameKwak, Jin Young-
dc.contributor.alternativeNameKim, Eun Kyung-
dc.contributor.alternativeNameMoon, Heui Jeong-
dc.contributor.alternativeNameYoon, Jung Hyun-
dc.contributor.alternativeNameChung, Woung Youn-
dc.contributor.alternativeNameChoi, Jong Rak-
dc.contributor.affiliatedAuthorKwak, Jin Young-
dc.contributor.affiliatedAuthorKim, Eun-Kyung-
dc.contributor.affiliatedAuthorMoon, Heui Jeong-
dc.contributor.affiliatedAuthorYoon, Jung Hyun-
dc.contributor.affiliatedAuthorChung, Woung Youn-
dc.contributor.affiliatedAuthorChoi, Jong Rak-
dc.rights.accessRightsnot free-
dc.citation.volume18-
dc.citation.number3-
dc.citation.startPage792-
dc.citation.endPage799-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.18(3) : 792-799, 2011-
dc.identifier.rimsid28671-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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