Cited 21 times in
Diagnostic value of BRAF(V600E) mutation analysis of thyroid nodules according to ultrasonographic features and the time of aspiration.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 곽진영 | - |
dc.contributor.author | 김은경 | - |
dc.contributor.author | 문희정 | - |
dc.contributor.author | 윤정현 | - |
dc.contributor.author | 정웅윤 | - |
dc.contributor.author | 최종락 | - |
dc.date.accessioned | 2014-12-20T16:23:58Z | - |
dc.date.available | 2014-12-20T16:23:58Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92642 | - |
dc.description.abstract | BACKGROUND: We investigated the diagnostic value of the BRAF(V600E) mutation of thyroid nodules according to ultrasonography (US) features and the time of BRAF(V600E) mutation analysis. METHODS: A total of 304 nodules in 295 patients (mean age, 49.4 years) were included. Thyroid nodules were classified as suspicious or probably benign on US. Group 1 (n = 168) included nodules with BRAF(V600E) mutation analysis at the time of the initial US-guided fine needle aspiration biopsy (US-FNAB) and group 2 (n = 136) included nodules with analysis at the time of the repeat US-FNAB. The frequency of malignancy and the BRAF(V600E) mutation were compared between suspicious and probably benign nodules on US and between groups 1 and 2. RESULTS: Of 304 nodules, 113 were malignant and 59 (52.2%) had the BRAF(V600E) mutation. Also, 58 of 196 nodules suspicious on US (29.6%) had the BRAF(V600E) mutation, whereas 1 of 108 (0.9%) probably benign nodules had the BRAF(V600E) mutation (P value <.0001). The BRAF(V600E) mutation was more frequently found in nodules suspicious on US than those probably benign in both groups 1 and 2 (P value <.0001 and .0058, respectively). Preoperative detection of the BRAF(V600E) mutation led surgeons to perform surgery in 5.8% of 103 nodules with benign and nondiagnostic results on cytology in group 1 and 1% of 98 nodules in group 2 without treatment delay. CONCLUSIONS: The BRAF(V600E) mutation analysis was a useful adjunctive diagnostic tool, especially in nodules suspicious on US, and was more effective if performed at the time of the initial US-FNAB. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 792~799 | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biopsy, Fine-Needle | - |
dc.subject.MESH | Carcinoma, Papillary/diagnosticimaging | - |
dc.subject.MESH | Carcinoma, Papillary/genetics* | - |
dc.subject.MESH | Carcinoma, Papillary/pathology | - |
dc.subject.MESH | DNA MutationalAnalysis | - |
dc.subject.MESH | Diagnosis, Differential | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation/genetics* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proto-Oncogene Proteins B-raf/genetics* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | ThyroidNeoplasms/diagnosticimaging | - |
dc.subject.MESH | ThyroidNeoplasms/genetics* | - |
dc.subject.MESH | ThyroidNeoplasms/pathology | - |
dc.subject.MESH | ThyroidNodule/diagnosticimaging | - |
dc.subject.MESH | ThyroidNodule/genetics* | - |
dc.subject.MESH | ThyroidNodule/pathology | - |
dc.subject.MESH | TimeFactors | - |
dc.subject.MESH | Ultrasonography | - |
dc.subject.MESH | Young Adult | - |
dc.title | Diagnostic value of BRAF(V600E) mutation analysis of thyroid nodules according to ultrasonographic features and the time of aspiration. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Hee Jung Moon | - |
dc.contributor.googleauthor | Eun-Kyung Kim | - |
dc.contributor.googleauthor | Woong Youn Chung | - |
dc.contributor.googleauthor | Jong Rak Choi | - |
dc.contributor.googleauthor | Jung Hyun Yoon | - |
dc.contributor.googleauthor | Jin Young Kwak | - |
dc.identifier.doi | 10.1245/s10434-010-1354-z | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00182 | - |
dc.contributor.localId | A00801 | - |
dc.contributor.localId | A01397 | - |
dc.contributor.localId | A02595 | - |
dc.contributor.localId | A03674 | - |
dc.contributor.localId | A04182 | - |
dc.relation.journalcode | J00179 | - |
dc.identifier.eissn | 1534-4681 | - |
dc.identifier.pmid | 20945104 | - |
dc.identifier.url | http://link.springer.com/article/10.1245%2Fs10434-010-1354-z | - |
dc.subject.keyword | Papillary Thyroid Carcinoma | - |
dc.subject.keyword | Thyroid Nodule | - |
dc.subject.keyword | Benign Nodule BRAFV600E Mutation | - |
dc.subject.keyword | Indeterminate Result | - |
dc.contributor.alternativeName | Kwak, Jin Young | - |
dc.contributor.alternativeName | Kim, Eun Kyung | - |
dc.contributor.alternativeName | Moon, Heui Jeong | - |
dc.contributor.alternativeName | Yoon, Jung Hyun | - |
dc.contributor.alternativeName | Chung, Woung Youn | - |
dc.contributor.alternativeName | Choi, Jong Rak | - |
dc.contributor.affiliatedAuthor | Kwak, Jin Young | - |
dc.contributor.affiliatedAuthor | Kim, Eun-Kyung | - |
dc.contributor.affiliatedAuthor | Moon, Heui Jeong | - |
dc.contributor.affiliatedAuthor | Yoon, Jung Hyun | - |
dc.contributor.affiliatedAuthor | Chung, Woung Youn | - |
dc.contributor.affiliatedAuthor | Choi, Jong Rak | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 18 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 792 | - |
dc.citation.endPage | 799 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, Vol.18(3) : 792-799, 2011 | - |
dc.identifier.rimsid | 28671 | - |
dc.type.rims | ART | - |
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