3 142

Cited 0 times in

Molecular imaging with terahertz waves

Authors
 Seung Jae Oh  ;  Jihye Choi  ;  Inhee Maeng  ;  Jae Yeon Park  ;  Kwangyeol Lee  ;  Yong-Min Huh  ;  Jin-Suck Suh  ;  Seungjoo Haam  ;  Joo-Hiuk Son 
Citation
 Optics Express, Vol.19(5) : 4009-4016, 2011 
Journal Title
 Optics Express 
ISSN
 1094-4087 
Issue Date
2011
Abstract
We demonstrate a highly sensitive THz molecular imaging (TMI) technique involving differential modulation of surface plasmons induced on nanoparticles and obtain target specific in vivo images of cancers. This technique can detect quantities of gold nanoparticles as small as 15 µM in vivo. A comparison of TMI images with near infrared absorption images shows the superior sensitivity of TMI. Furthermore, the quantification property of TMI is excellent, being linearly proportional to the concentration of nanoparticles. The target specificity issue is also addressed at the ex vivo and cell levels. The high thermal sensitivity of TMI can help extend photonic-based photothermal molecular imaging researches from the in vitro level to the in vivo level. The TMI technique can be used for monitoring drug delivery processes and for early cancer diagnosis.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92582
DOI
10.1364/OE.19.004009
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute for Medical Convergence (연의-생공연 메디컬융합연구소)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
서진석(Suh, Jin Suck) ; 오승재(Oh, Seung Jae) ; 허용민(Huh, Yong Min)
사서에게 알리기
  feedback
Full Text
http://www.opticsinfobase.org/oe/abstract.cfm?uri=oe-19-5-4009
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse