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Neurorestoration induced by mesenchymal stem cells: potential therapeutic mechanisms for clinical trials

Authors
 Jung Hwa Seo  ;  Sung-Rae Cho 
Citation
 YONSEI MEDICAL JOURNAL, Vol.53(6) : 1059-1067, 2012 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2012
MeSH
Cell Differentiation/physiology ; Cell- and Tissue-Based Therapy/methods ; Clinical Trials as Topic ; Humans ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stromal Cells/cytology* ; Mesenchymal Stromal Cells/physiology ; Models, Biological ; Nervous System Diseases/metabolism ; Nervous System Diseases/therapy* ; Neurogenesis/physiology
Keywords
Mesenchymal stem cells ; paracrine effect ; cell-based therapy
Abstract
Stem cells are emerging as therapeutic candidates in a variety of diseases because of their multipotent capacities. Among these, mesenchymal stem cells (MSCs) derived from bone marrow, umbilical cord blood or adipose tissue, comprise a population of cells that exhibit extensive proliferative potential and retain the ability to differentiate into multiple tissue-specific lineage cells including osteoblasts, chondrocytes, and adipocytes. MSCs have also been shown to enhance neurological recovery, although the therapeutic effects seem to be derived from an indirect paracrine effect rather than direct cell replacement. MSCs secrete neurotrophic factors, promote endogenous neurogenesis and angiogenesis, encourage synaptic connection and remyelination of damaged axons, decrease apoptosis, and regulate inflammation primarily through paracrine actions. Accordingly, MSCs may prevail as a promising cell source for cell-based therapy in neurological diseases.
Files in This Item:
T201203157.pdf Download
DOI
23074102
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Seo, Jung Hwa(서정화)
Cho, Sung-Rae(조성래) ORCID logo https://orcid.org/0000-0003-1429-2684
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92129
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