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Neurorestoration induced by mesenchymal stem cells: potential therapeutic mechanisms for clinical trials

DC Field Value Language
dc.contributor.author서정화-
dc.contributor.author조성래-
dc.date.accessioned2014-12-19T17:49:30Z-
dc.date.available2014-12-19T17:49:30Z-
dc.date.issued2012-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92129-
dc.description.abstractStem cells are emerging as therapeutic candidates in a variety of diseases because of their multipotent capacities. Among these, mesenchymal stem cells (MSCs) derived from bone marrow, umbilical cord blood or adipose tissue, comprise a population of cells that exhibit extensive proliferative potential and retain the ability to differentiate into multiple tissue-specific lineage cells including osteoblasts, chondrocytes, and adipocytes. MSCs have also been shown to enhance neurological recovery, although the therapeutic effects seem to be derived from an indirect paracrine effect rather than direct cell replacement. MSCs secrete neurotrophic factors, promote endogenous neurogenesis and angiogenesis, encourage synaptic connection and remyelination of damaged axons, decrease apoptosis, and regulate inflammation primarily through paracrine actions. Accordingly, MSCs may prevail as a promising cell source for cell-based therapy in neurological diseases.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1059~1067-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCell Differentiation/physiology-
dc.subject.MESHCell- and Tissue-Based Therapy/methods-
dc.subject.MESHClinical Trials as Topic-
dc.subject.MESHHumans-
dc.subject.MESHMesenchymal Stem Cell Transplantation-
dc.subject.MESHMesenchymal Stromal Cells/cytology*-
dc.subject.MESHMesenchymal Stromal Cells/physiology-
dc.subject.MESHModels, Biological-
dc.subject.MESHNervous System Diseases/metabolism-
dc.subject.MESHNervous System Diseases/therapy*-
dc.subject.MESHNeurogenesis/physiology-
dc.titleNeurorestoration induced by mesenchymal stem cells: potential therapeutic mechanisms for clinical trials-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorJung Hwa Seo-
dc.contributor.googleauthorSung-Rae Cho-
dc.identifier.doi23074102-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01906-
dc.contributor.localIdA03831-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid23074102-
dc.subject.keywordMesenchymal stem cells-
dc.subject.keywordparacrine effect-
dc.subject.keywordcell-based therapy-
dc.contributor.alternativeNameSeo, Jung Hwa-
dc.contributor.alternativeNameCho, Sung Rae-
dc.contributor.affiliatedAuthorSeo, Jung Hwa-
dc.contributor.affiliatedAuthorCho, Sung Rae-
dc.citation.volume53-
dc.citation.number6-
dc.citation.startPage1059-
dc.citation.endPage1067-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.53(6) : 1059-1067, 2012-
dc.identifier.rimsid29634-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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