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Phagocytosis and endocytosis of silver nanoparticles induce interleukin-8 production in human macrophages. Kim S, Choi IH.

Authors
 Seungjae Kim  ;  In-Hong Choi 
Citation
 YONSEI MEDICAL JOURNAL, Vol.53(3) : 654-657, 2012 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2012
MeSH
Cell Line ; Cell Survival/drug effects ; Endocytosis/physiology* ; Humans ; Interleukin-8/metabolism* ; Macrophages/drug effects ; Macrophages/metabolism* ; Metal Nanoparticles/chemistry* ; Phagocytosis/physiology* ; Silver/chemistry* ; Silver/pharmacology
Keywords
Silver nanoparticles ; macrophages ; endocytosis ; phagocytosis ; IL-8
Abstract
Phagocytosis or endocytosis by macrophages is critical to the uptake of fine particles, including nanoparticles, in order to initiate toxic effects in cells. Here, our data enhance the understanding of the process of internalization of silver nanoparticles by macrophages. When macrophages were pre-treated with inhibitors to phagocytosis, caveolin-mediated endocytosis, or clathrin-mediated endocytosis, prior to exposure to silver nanoparticles, Interleukin-8 (IL-8) production was inhibited. Although cell death was not reduced, the inflammatory response by macrophages was compromised by phagocytosis and endocytosis inhibitors.
Files in This Item:
T201201178.pdf Download
DOI
22477013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Choi, In Hong(최인홍) ORCID logo https://orcid.org/0000-0001-9851-0137
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92083
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