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β-PIX is critical for transplanted mesenchymal stromal cell migration

Authors
 Seong-Ho Koh  ;  Yong-Min Huh  ;  Min Young Noh  ;  Hyun Young Kim  ;  Kyung Suk Kim  ;  Eun-Sook Lee  ;  Hyun-Ju Ko  ;  Goang Won Cho  ;  A. Rum Yoo  ;  Ho-taek Song  ;  Sejin Hwang  ;  Kwangyeol Lee  ;  Seungjoo Haam  ;  Joseph A. Frank  ;  Jin-Suck Suh  ;  Seung Hyun Kim 
Citation
 Stem Cells and Development, Vol.21(11) : 1989-1999, 2012 
Journal Title
 Stem Cells and Development 
ISSN
 1547-3287 
Issue Date
2012
Abstract
Bone marrow-derived mesenchymal stromal cells (MSCs) have been used successfully as a source of stem cells for treating neurodegenerative diseases. However, for reasons that are not clear, autologous MSC transplants have not yielded successful results in human trials. To test one possible reason, we compared the migratory ability of MSCs from amyotrophic lateral sclerosis (ALS) patients with those of healthy controls. We found that MSCs derived from ALS patients (ALS-MSCs) had a reduced ability to migrate, which may explain why autologous transplantation is not successful. We also found that expression of one of the intracellular factors implicated in migration, β-PIX, was significantly reduced in ALS-MSCs compared with healthy stem cells. Restoration of β-PIX expression by genetic manipulation restored the migratory ability of ALS-MSCs, and inhibition of β-PIX expression with shRNA reduced the migration of healthy MSCs. We suggest that transplantation of allogeneic or genetically modified autologous stem cells might be a more promising strategy for ALS patients than transplantation of autologous stem cells.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91872
DOI
10.1089/scd.2011.0430
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
고현주(Ko, Hyun Ju)
서진석(Suh, Jin Suck)
송호택(Song, Ho Taek)
이은숙(Lee, Eun Sook)
허용민(Huh, Yong Min)
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Full Text
http://online.liebertpub.com/doi/abs/10.1089/scd.2011.0430
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