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FKBP5 polymorphisms as vulnerability to anxiety and depression in patients with advanced gastric cancer: a controlled and prospective study

 Jee In Kang  ;  Hyun Cheol Chung  ;  Hei-Cheul Jeung  ;  Se Joo Kim  ;  Suk Kyoon An  ;  Kee Namkoong 
 PSYCHONEUROENDOCRINOLOGY, Vol.37(9) : 1569-1576, 2012 
Journal Title
Issue Date
Adaptation, Psychological ; Adult ; Aged ; Alleles ; Anxiety/complications ; Anxiety/genetics* ; Anxiety/physiopathology ; Depression/complications ; Depression/genetics* ; Depression/physiopathology ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Hypothalamo-Hypophyseal System/physiopathology ; Male ; Middle Aged ; Pituitary-Adrenal System/physiopathology ; Polymorphism, Single Nucleotide ; Psychiatric Status Rating Scales ; Stomach Neoplasms/complications* ; Stomach Neoplasms/physiopathology ; Stomach Neoplasms/psychology ; Stress, Psychological/complications ; Stress, Psychological/genetics* ; Stress, Psychological/physiopathology ; Tacrolimus Binding Proteins/genetics*
Cancer ; Stress ; FKBP5 ; HPA axis ; Depression ; Anxiety ; Gene
Cancer patients, who have to adapt to a long treatment process with multiple stressful events, show various stress responses. Genetic components may contribute to individual differences in stress response and risk for development of stress-related psychiatric problems. The present study aimed to investigate the influence of FK506 binding protein 5 (FKBP5) gene polymorphisms regulating the hypothalamic-pituitary-adrenal (HPA) axis on individual distress levels in cancer patients faced with similar stressful situation. The present study used a prospective design to elucidate predictors of distress. A total of 130 patients (90 males, 40 females) who were newly diagnosed with advanced gastric cancer and supposed to receive first-line chemotherapy were initially assessed, and a six-week follow-up assessment occurred for 93 patients (63 males, 30 females) after two cycles of chemotherapy. Distress levels and coping patterns were measured by the Hospital Anxiety and Depression Scale (HADS) and Mini-Mental Adjustment to Cancer (Mini-MAC) scale. For genetic factors, three single nucleotide polymorphisms of FKBP5 rs1360780, rs9296158 and rs9470080 were genotyped. For HADS-anxiety, FKBP5 rs9296158 had a significant group-by-time interaction (p=0.015), and rs9470080 and rs1360780 had a marginally significant interaction (p=0.023, p=0.038, respectively). For HADS-depression, rs9470080 and rs9296158 had a marginally significant group-by-time interaction (p=0.026, p=0.032, respectively). In addition, a step-wise linear regression analysis showed that FKBP5 rs9470080 and rs9296158 were significant predictors of anxiety and depression after prolonged stress exposure in cancer patients. Our findings indicate that the genetic factors regulating the HPA axis such as FKBP5 gene polymorphisms may play a crucial role in anxiety and depression following prolonged stress exposure.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Namkoong, Kee(남궁기) ORCID logo https://orcid.org/0000-0003-1400-8057
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
Jeung, Hei Cheul(정희철) ORCID logo https://orcid.org/0000-0003-0952-3679
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