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AMPK γ2 subunit gene PRKAG2 polymorphism associated with cognitive impairment as well as diabetes in old age

Authors
 Kim Eosu  ;  Lee Sung Hee  ;  Lee Kang Soo  ;  Cheong Hae-Kwan  ;  Namkoong Kee  ;  Hong Chang Hyung  ;  Oh Byoung Hoon 
Citation
 Psychoneuroendocrinology, Vol.37(3) : 358-365, 2012 
Journal Title
 Psychoneuroendocrinology 
ISSN
 0306-4530 
Issue Date
2012
Abstract
Metabolic and cognitive disorders are closely related. However, the molecular mechanism underlying this association is still elusive. Given the importance of energy metabolism in neuronal cells, AMP-activated protein kinase (AMPK), a master switch of energy metabolism, could be an independent factor affecting cognitive as well as metabolic functions. Therefore, we examined the relationship between the AMPK γ2 gene, the PRKAG2 -26C/T polymorphism and cognitive impairment or diabetes in 1609 subjects aged from 60 to 80. We performed multivariate logistic regression analyses with adjustment for age, gender, education, smoking, alcohol, depression, waist circumference, APOE e4, and stroke history. We found a significant association between the -26C/T polymorphism (CC vs. CT/TT) and cognitive impairment (OR, 1.6; 95% CI, 1.1-2.3). Moreover, this polymorphism (CC/CT vs. TT) was also related to the presence of diabetes (OR, 1.8; 95% CI, 1.2-2.8). Importantly, the relationship with cognitive impairment was still significant in non-diabetic individuals (OR, 1.6; 95% CI, 1.1-2.4). Further analyses with a subpopulation (n=611) revealed that CC homozygotes relative to T-allele carriers had significantly better performances in verbal memory and attentional tasks. These findings collectively support a hypothesis that AMPK has a role not only in metabolic functioning but also in cognitive functioning in humans. Extended longitudinal study with a larger number of samples is warranted.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91765
DOI
10.1016/j.psyneuen.2011.07.005
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
Yonsei Authors
김어수(Kim, Eosu)
남궁기(Namkoong, Kee)
오병훈(Oh, Byong Hoon)
이성희(Lee, Sung Hee)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0306453011001909
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