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AMPK γ2 subunit gene PRKAG2 polymorphism associated with cognitive impairment as well as diabetes in old age

DC FieldValueLanguage
dc.contributor.author김어수-
dc.contributor.author남궁기-
dc.contributor.author오병훈-
dc.contributor.author이성희-
dc.date.accessioned2014-12-19T17:37:38Z-
dc.date.available2014-12-19T17:37:38Z-
dc.date.issued2012-
dc.identifier.issn0306-4530-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91765-
dc.description.abstractMetabolic and cognitive disorders are closely related. However, the molecular mechanism underlying this association is still elusive. Given the importance of energy metabolism in neuronal cells, AMP-activated protein kinase (AMPK), a master switch of energy metabolism, could be an independent factor affecting cognitive as well as metabolic functions. Therefore, we examined the relationship between the AMPK γ2 gene, the PRKAG2 -26C/T polymorphism and cognitive impairment or diabetes in 1609 subjects aged from 60 to 80. We performed multivariate logistic regression analyses with adjustment for age, gender, education, smoking, alcohol, depression, waist circumference, APOE e4, and stroke history. We found a significant association between the -26C/T polymorphism (CC vs. CT/TT) and cognitive impairment (OR, 1.6; 95% CI, 1.1-2.3). Moreover, this polymorphism (CC/CT vs. TT) was also related to the presence of diabetes (OR, 1.8; 95% CI, 1.2-2.8). Importantly, the relationship with cognitive impairment was still significant in non-diabetic individuals (OR, 1.6; 95% CI, 1.1-2.4). Further analyses with a subpopulation (n=611) revealed that CC homozygotes relative to T-allele carriers had significantly better performances in verbal memory and attentional tasks. These findings collectively support a hypothesis that AMPK has a role not only in metabolic functioning but also in cognitive functioning in humans. Extended longitudinal study with a larger number of samples is warranted.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPSYCHONEUROENDOCRINOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAMP-Activated Protein Kinases/genetics*-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAlleles-
dc.subject.MESHCognition Disorders/genetics*-
dc.subject.MESHDiabetes Mellitus/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Association Studies/methods-
dc.subject.MESHGenotype-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPolymorphism, Genetic-
dc.subject.MESHPsychomotor Performance-
dc.titleAMPK γ2 subunit gene PRKAG2 polymorphism associated with cognitive impairment as well as diabetes in old age-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학)-
dc.contributor.googleauthorKim Eosu-
dc.contributor.googleauthorLee Sung Hee-
dc.contributor.googleauthorLee Kang Soo-
dc.contributor.googleauthorCheong Hae-Kwan-
dc.contributor.googleauthorNamkoong Kee-
dc.contributor.googleauthorHong Chang Hyung-
dc.contributor.googleauthorOh Byoung Hoon-
dc.identifier.doi21813245-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00686-
dc.contributor.localIdA01240-
dc.contributor.localIdA02368-
dc.contributor.localIdA02876-
dc.relation.journalcodeJ02572-
dc.identifier.eissn1873-3360-
dc.identifier.pmid21813245-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0306453011001909-
dc.subject.keywordAMP-activated protein kinase-
dc.subject.keywordCognitive impairment-
dc.subject.keywordDiabetes-
dc.subject.keywordGenetic polymorphism-
dc.contributor.alternativeNameKim, Eo Su-
dc.contributor.alternativeNameNamkoong, Kee-
dc.contributor.alternativeNameOh, Byong Hoon-
dc.contributor.alternativeNameLee, Sung Hee-
dc.contributor.affiliatedAuthorKim, Eo Su-
dc.contributor.affiliatedAuthorNamkoong, Kee-
dc.contributor.affiliatedAuthorOh, Byong Hoon-
dc.contributor.affiliatedAuthorLee, Sung Hee-
dc.citation.volume37-
dc.citation.number3-
dc.citation.startPage358-
dc.citation.endPage365-
dc.identifier.bibliographicCitationPSYCHONEUROENDOCRINOLOGY, Vol.37(3) : 358-365, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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