0 276

Cited 31 times in

The relationship of platelet count, mean platelet volume with metabolic syndrome according to the criteria of the American Association of Clinical Endocrinologists: a focus on gender differences

 Byoung-Jin Park  ;  Jae-Yong Shim  ;  Hye-Ree Lee  ;  Dong-Hyuk Jung  ;  Jung-Hyun Lee  ;  Yong-Jae Lee 
 Platelets, Vol.23(1) : 45-50, 2012 
Journal Title
Issue Date
Metabolic syndrome (MS) is becoming globally prevalent and it is clinically important because of its association with type 2 diabetes and cardiovascular disease, and some cancers. Recently, platelet count has been linked to insulin resistance and MS in addition to being a marker of hemostasis. Also, mean platelet volume (MPV) has been known to represent platelet activity. Platelet counts and MPV are modified by various biosocial and lifestyle factors such as race, age, gender, smoking habit, alcohol consumption, and physical activity. Thus, the direction and magnitude of this association may differ by gender. In this regard, proper interpretion of platelet counts and MPV by gender could be important in the people with MS. We examined the relationship between platelet counts, MPV, and MS through gender-specific analyses for 3827 Korean adults (2169 men and 1658 women) in a health examination program. In women, platelet counts were significantly higher in subjects with MS compared to in those without MS (p < 0.001), whereas MPV was significantly lower (p = 0.001). However, no such trend was observed in men. Multiple regression analyses also showed that MS is positively associated with platelet counts and inversely associated with MPV, independently of confounding variables only in women. The results suggest that platelet counts and MPV might be a surrogate marker associated with clustered MS in women.
Full Text
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)
Yonsei Authors
박병진(Park, Byoung Jin) ORCID logo https://orcid.org/0000-0003-1733-5301
심재용(Shim, Jae Yong) ORCID logo https://orcid.org/0000-0002-9561-9230
이용제(Lee, Yong Jae) ORCID logo https://orcid.org/0000-0002-6697-476X
이혜리(Lee, Hye Ree)
정동혁(Jung, Dong Hyuk) ORCID logo https://orcid.org/0000-0002-3411-0676
RIS (EndNote)
XLS (Excel)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.