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The relationship of platelet count, mean platelet volume with metabolic syndrome according to the criteria of the American Association of Clinical Endocrinologists: a focus on gender differences

DC FieldValueLanguage
dc.contributor.author박병진-
dc.contributor.author심재용-
dc.contributor.author이혜리-
dc.contributor.author정동혁-
dc.contributor.author이용제-
dc.date.accessioned2014-12-19T17:34:42Z-
dc.date.available2014-12-19T17:34:42Z-
dc.date.issued2012-
dc.identifier.issn0953-7104-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91672-
dc.description.abstractMetabolic syndrome (MS) is becoming globally prevalent and it is clinically important because of its association with type 2 diabetes and cardiovascular disease, and some cancers. Recently, platelet count has been linked to insulin resistance and MS in addition to being a marker of hemostasis. Also, mean platelet volume (MPV) has been known to represent platelet activity. Platelet counts and MPV are modified by various biosocial and lifestyle factors such as race, age, gender, smoking habit, alcohol consumption, and physical activity. Thus, the direction and magnitude of this association may differ by gender. In this regard, proper interpretion of platelet counts and MPV by gender could be important in the people with MS. We examined the relationship between platelet counts, MPV, and MS through gender-specific analyses for 3827 Korean adults (2169 men and 1658 women) in a health examination program. In women, platelet counts were significantly higher in subjects with MS compared to in those without MS (p < 0.001), whereas MPV was significantly lower (p = 0.001). However, no such trend was observed in men. Multiple regression analyses also showed that MS is positively associated with platelet counts and inversely associated with MPV, independently of confounding variables only in women. The results suggest that platelet counts and MPV might be a surrogate marker associated with clustered MS in women.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfPlatelets-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAsian Continental Ancestry Group-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBlood Platelets/pathology*-
dc.subject.MESHCell Size*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMetabolic Syndrome/blood*-
dc.subject.MESHMetabolic Syndrome/epidemiology-
dc.subject.MESHMetabolic Syndrome/pathology*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPlatelet Count-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHSex Characteristics*-
dc.titleThe relationship of platelet count, mean platelet volume with metabolic syndrome according to the criteria of the American Association of Clinical Endocrinologists: a focus on gender differences-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학)-
dc.contributor.googleauthorByoung-Jin Park-
dc.contributor.googleauthorJae-Yong Shim-
dc.contributor.googleauthorHye-Ree Lee-
dc.contributor.googleauthorDong-Hyuk Jung-
dc.contributor.googleauthorJung-Hyun Lee-
dc.contributor.googleauthorYong-Jae Lee-
dc.identifier.doi21736420-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01477-
dc.contributor.localIdA02207-
dc.contributor.localIdA03595-
dc.contributor.localIdA03310-
dc.relation.journalcodeJ02535-
dc.identifier.pmid21736420-
dc.identifier.urlhttp://informahealthcare.com/doi/abs/10.3109/09537104.2011.589014-
dc.subject.keywordPlatelet count-
dc.subject.keywordmean platelet volume-
dc.subject.keywordobesity-
dc.subject.keywordmetabolic syndrome-
dc.subject.keywordgender difference-
dc.contributor.alternativeNamePark, Byoung Jin-
dc.contributor.alternativeNameShim, Jae Yong-
dc.contributor.alternativeNameLee, Hye Ree-
dc.contributor.alternativeNameJung, Dong Hyuk-
dc.contributor.affiliatedAuthorPark, Byoung Jin-
dc.contributor.affiliatedAuthorShim, Jae Yong-
dc.contributor.affiliatedAuthorJung, Dong Hyuk-
dc.contributor.affiliatedAuthorLee, Hye Ree-
dc.citation.volume23-
dc.citation.number1-
dc.citation.startPage45-
dc.citation.endPage50-
dc.identifier.bibliographicCitationPlatelets, Vol.23(1) : 45-50, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers

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