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Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells

Authors
 SOO‑HYUN HAHM  ;  JI HYUNG CHUNG  ;  LIA AGUSTINA  ;  SE‑HEE HAN  ;  IN‑SOO YOON  ;  JONG‑HWA PARK  ;  LIN‑WOO KANG  ;  JIN WOO PARK  ;  JONG JOO NA  ;  YE SUN HAN 
Citation
 ONCOLOGY LETTERS, Vol.4(6) : 1203-1208, 2012 
Journal Title
 ONCOLOGY LETTERS 
ISSN
 1792-1074 
Issue Date
2012
Keywords
human MutY homolog ; ataxia telangiectasia mutated ; Rad3-related protein ; topoisomerase-binding protein-1 ; apoptosis ; etoposide
Abstract
Etoposide (ETP) treatment of ataxia telangiectasia mutated (ATM) and Rad3-related protein (ATR)-, topoisomerase-binding protein-1 (TopBP1) and human MutY homolog (hMYH)-depleted cells results in a significant reduction in apoptotic signaling. The association between ATR or TopBP1 and hMYH increased following ETP treatment. In hMYH knockdown cells, the interaction between ATR and TopBP1 decreased following ETP treatment. We suggest that hMYH functions as a sensor of ETP-induced apoptosis. The results suggest that in the absence of hMYH, cells are unable to recognize the damage signal and the ATR pathway is not activated.
Files in This Item:
T201203757.pdf Download
DOI
23226797
Appears in Collections:
5. Research Institutes (연구소) > Cardiovascular Product Evaluation Center (심혈관제품유효성평가센터) > 1. Journal Papers
Yonsei Authors
Chung, Ji Hyung(정지형)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91590
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