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Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells
DC Field | Value | Language |
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dc.contributor.author | 정지형 | - |
dc.date.accessioned | 2014-12-19T17:32:08Z | - |
dc.date.available | 2014-12-19T17:32:08Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1792-1074 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91590 | - |
dc.description.abstract | Etoposide (ETP) treatment of ataxia telangiectasia mutated (ATM) and Rad3-related protein (ATR)-, topoisomerase-binding protein-1 (TopBP1) and human MutY homolog (hMYH)-depleted cells results in a significant reduction in apoptotic signaling. The association between ATR or TopBP1 and hMYH increased following ETP treatment. In hMYH knockdown cells, the interaction between ATR and TopBP1 decreased following ETP treatment. We suggest that hMYH functions as a sensor of ETP-induced apoptosis. The results suggest that in the absence of hMYH, cells are unable to recognize the damage signal and the ATR pathway is not activated. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | ONCOLOGY LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Yonsei Cardiovascular Research Institute (심혈관연구소) | - |
dc.contributor.googleauthor | SOO‑HYUN HAHM | - |
dc.contributor.googleauthor | JI HYUNG CHUNG | - |
dc.contributor.googleauthor | LIA AGUSTINA | - |
dc.contributor.googleauthor | SE‑HEE HAN | - |
dc.contributor.googleauthor | IN‑SOO YOON | - |
dc.contributor.googleauthor | JONG‑HWA PARK | - |
dc.contributor.googleauthor | LIN‑WOO KANG | - |
dc.contributor.googleauthor | JIN WOO PARK | - |
dc.contributor.googleauthor | JONG JOO NA | - |
dc.contributor.googleauthor | YE SUN HAN | - |
dc.identifier.doi | 23226797 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03739 | - |
dc.relation.journalcode | J02417 | - |
dc.identifier.eissn | 1792-1082 | - |
dc.identifier.pmid | 23226797 | - |
dc.subject.keyword | human MutY homolog | - |
dc.subject.keyword | ataxia telangiectasia mutated | - |
dc.subject.keyword | Rad3-related protein | - |
dc.subject.keyword | topoisomerase-binding protein-1 | - |
dc.subject.keyword | apoptosis | - |
dc.subject.keyword | etoposide | - |
dc.contributor.alternativeName | Chung, Ji Hyung | - |
dc.contributor.affiliatedAuthor | Chung, Ji Hyung | - |
dc.citation.volume | 4 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1203 | - |
dc.citation.endPage | 1208 | - |
dc.identifier.bibliographicCitation | ONCOLOGY LETTERS, Vol.4(6) : 1203-1208, 2012 | - |
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