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Human MutY homolog induces apoptosis in etoposide-treated HEK293 cells

DC FieldValueLanguage
dc.contributor.author정지형-
dc.date.accessioned2014-12-19T17:32:08Z-
dc.date.available2014-12-19T17:32:08Z-
dc.date.issued2012-
dc.identifier.issn1792-1074-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91590-
dc.description.abstractEtoposide (ETP) treatment of ataxia telangiectasia mutated (ATM) and Rad3-related protein (ATR)-, topoisomerase-binding protein-1 (TopBP1) and human MutY homolog (hMYH)-depleted cells results in a significant reduction in apoptotic signaling. The association between ATR or TopBP1 and hMYH increased following ETP treatment. In hMYH knockdown cells, the interaction between ATR and TopBP1 decreased following ETP treatment. We suggest that hMYH functions as a sensor of ETP-induced apoptosis. The results suggest that in the absence of hMYH, cells are unable to recognize the damage signal and the ATR pathway is not activated.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfONCOLOGY LETTERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHuman MutY homolog induces apoptosis in etoposide-treated HEK293 cells-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentYonsei Cardiovascular Research Institute (심혈관연구소)-
dc.contributor.googleauthorSOO‑HYUN HAHM-
dc.contributor.googleauthorJI HYUNG CHUNG-
dc.contributor.googleauthorLIA AGUSTINA-
dc.contributor.googleauthorSE‑HEE HAN-
dc.contributor.googleauthorIN‑SOO YOON-
dc.contributor.googleauthorJONG‑HWA PARK-
dc.contributor.googleauthorLIN‑WOO KANG-
dc.contributor.googleauthorJIN WOO PARK-
dc.contributor.googleauthorJONG JOO NA-
dc.contributor.googleauthorYE SUN HAN-
dc.identifier.doi23226797-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03739-
dc.relation.journalcodeJ02417-
dc.identifier.eissn1792-1082-
dc.identifier.pmid23226797-
dc.subject.keywordhuman MutY homolog-
dc.subject.keywordataxia telangiectasia mutated-
dc.subject.keywordRad3-related protein-
dc.subject.keywordtopoisomerase-binding protein-1-
dc.subject.keywordapoptosis-
dc.subject.keywordetoposide-
dc.contributor.alternativeNameChung, Ji Hyung-
dc.contributor.affiliatedAuthorChung, Ji Hyung-
dc.citation.volume4-
dc.citation.number6-
dc.citation.startPage1203-
dc.citation.endPage1208-
dc.identifier.bibliographicCitationONCOLOGY LETTERS, Vol.4(6) : 1203-1208, 2012-
Appears in Collections:
5. Research Institutes (연구소) > Cardiovascular Product Evaluation Center (심혈관제품유효성평가센터) > 1. Journal Papers

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