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Comparing quantitative tractography metrics of motor and sensory pathways in children with periventricular leukomalacia and different levels of gross motor function

 Dong-wook Rha  ;  Won Hyuk Chang  ;  Jinna Kim  ;  Eun Geol Sim  ;  Eun Sook Park 
 NEURORADIOLOGY, Vol.54(6) : 615-621, 2012 
Journal Title
Issue Date
Cerebral Palsy/pathology* ; Cerebral Palsy/physiopathology* ; Child, Preschool ; Diffusion Tensor Imaging* ; Female ; Humans ; Infant ; Infant, Newborn ; Leukomalacia, Periventricular/pathology* ; Leukomalacia, Periventricular/physiopathology* ; Male ; Motor Cortex/pathology ; Motor Cortex/physiopathology ; Motor Skills ; Nerve Fibers, Myelinated/pathology* ; Neural Pathways/pathology ; Severity of Illness Index ; Somatosensory Cortex/pathology ; Somatosensory Cortex/physiopathology
Cerebral palsy ; Periventricular leukomalacia ; Diffusion tensor imaging ; Diffusion tensor tractography ; Gross motor function
INTRODUCTION: The neural tracts responsible for gross motor dysfunction in children with spastic cerebral palsy (CP) caused by periventricular leukomalacia remain unknown. This study investigated both sensory and motor tracts using diffusion tensor tractography (DTT). METHODS: Brain MRIs with diffusion tensor imaging (DTI) performed on 19 children (ten boys and nine girls) with bilateral spastic CP were analyzed. DTT was reconstructed from DTI. Participants were classified according to gross motor function measured with Gross Motor Function Classification System (GMFCS). Those with GMFCS levels I-III comprised the high-functioning group (n = 11), and those with GMFCS levels IV-V comprised the low-functioning group (n = 8). We compared DTT-based metrics, such as fractional anisotropy, apparent diffusion coefficient, and fiber number and volume, between the groups. RESULTS: In the corticospinal tract, the volume and number of fibers were significantly higher in the high-functioning group (p < 0.001), whereas the fractional anisotropy and apparent diffusion coefficient of the corticospinal tract did not differ significantly between the groups. In the somotosensory tract and posterior thalamic radiation, none of the DTT parameters differed significantly between the groups. CONCLUSIONS: Children with bilateral spastic CP with differing levels of gross motor function have corresponding differences detectable on DTT in their corticospinal tracts but not in their somatosensory tracts and posterior thalamic radiations. In addition, the number and volume of fibers, but not fractional anisotropy values or apparent diffusion coefficients, are lower in the corticospinal tracts in children with low gross motor function than in those with high gross motor function.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
Rha, Dong Wook(나동욱) ORCID logo https://orcid.org/0000-0002-7153-4937
Park, Eun Sook(박은숙) ORCID logo https://orcid.org/0000-0002-9144-3063
Sim, Eun Geol(심은결)
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