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Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status

Authors
 Seo Hee Choi  ;  Tae Min Jung  ;  Ji E. Lee  ;  Seung-Koo Lee  ;  Young H. Sohn  ;  Phil Hyu Lee 
Citation
 NEUROBIOLOGY OF AGING, Vol.33(7) : 1265-1272, 2012 
Journal Title
NEUROBIOLOGY OF AGING
ISSN
 0197-4580 
Issue Date
2012
MeSH
Aged ; Cognition Disorders/pathology* ; Cognition Disorders/psychology* ; Cognitive Dysfunction/pathology ; Cognitive Dysfunction/psychology ; Female ; Humans ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Organ Size ; Parkinson Disease/pathology* ; Parkinson Disease/psychology* ; Prospective Studies ; Substantia Innominata/pathology*
Keywords
Aged ; Cognition Disorders/pathology* ; Cognition Disorders/psychology* ; Cognitive Dysfunction/pathology ; Cognitive Dysfunction/psychology ; Female ; Humans ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Organ Size ; Parkinson Disease/pathology* ; Parkinson Disease/psychology* ; Prospective Studies ; Substantia Innominata/pathology*
Abstract
The cholinergic system arising from the substantia innominata (SI) of the basal forebrain has an important role in the cognitive functions of Parkinson's disease (PD). We performed magnetic resonance imaging based volumetric analysis to evaluate the SI volume in patients with PD-intact cognition (PD-IC), PD-mild cognitive impairment (PD-MCI), and PD dementia (PDD). The mean normalized SI volume was significantly decreased in patients with PD-IC (1.54 ± 0.12, p < 0.001), PD-MCI (1.49 ± 0.12, p < 0.001), and PDD (1.39 ± 0.12, p < 0.001) compared with that of control subjects (1.68 ± 0.11). The normalized SI volume did not differ between patients with PD-IC and PD-MCI; however, the normalized SI volume was significantly decreased in patients with PDD compared with that in those with PD-IC (p < 0.001) or PD-MCI (p = 0.016). The normalized SI volume was significantly correlated with general cognitive status (r = 0.51, p < 0.001) as well as with performance in each cognitive subdomain, with a particularly significant independent association with attention (β = 0.33, p = 0.003) and object naming (β = 0.26, p = 0.017). The present study demonstrated that the SI volume in PD differs depending on cognitive status and is significantly correlated with cognitive performance.
Full Text
http://www.sciencedirect.com/science/article/pii/S0197458010004987
DOI
21220177
10.1016/j.neurobiolaging.2010.11.015
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Lee, Ji Eun(이지은)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Choi, Seo Hee(최서희) ORCID logo https://orcid.org/0000-0002-4083-6414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91523
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