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Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status
DC Field | Value | Language |
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dc.contributor.author | 손영호 | - |
dc.contributor.author | 이승구 | - |
dc.contributor.author | 이지은 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 최서희 | - |
dc.date.accessioned | 2014-12-19T17:30:00Z | - |
dc.date.available | 2014-12-19T17:30:00Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91523 | - |
dc.description.abstract | The cholinergic system arising from the substantia innominata (SI) of the basal forebrain has an important role in the cognitive functions of Parkinson's disease (PD). We performed magnetic resonance imaging based volumetric analysis to evaluate the SI volume in patients with PD-intact cognition (PD-IC), PD-mild cognitive impairment (PD-MCI), and PD dementia (PDD). The mean normalized SI volume was significantly decreased in patients with PD-IC (1.54 ± 0.12, p < 0.001), PD-MCI (1.49 ± 0.12, p < 0.001), and PDD (1.39 ± 0.12, p < 0.001) compared with that of control subjects (1.68 ± 0.11). The normalized SI volume did not differ between patients with PD-IC and PD-MCI; however, the normalized SI volume was significantly decreased in patients with PDD compared with that in those with PD-IC (p < 0.001) or PD-MCI (p = 0.016). The normalized SI volume was significantly correlated with general cognitive status (r = 0.51, p < 0.001) as well as with performance in each cognitive subdomain, with a particularly significant independent association with attention (β = 0.33, p = 0.003) and object naming (β = 0.26, p = 0.017). The present study demonstrated that the SI volume in PD differs depending on cognitive status and is significantly correlated with cognitive performance. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | NEUROBIOLOGY OF AGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cognition Disorders/pathology* | - |
dc.subject.MESH | Cognition Disorders/psychology* | - |
dc.subject.MESH | Cognitive Dysfunction/pathology | - |
dc.subject.MESH | Cognitive Dysfunction/psychology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Organ Size | - |
dc.subject.MESH | Parkinson Disease/pathology* | - |
dc.subject.MESH | Parkinson Disease/psychology* | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Substantia Innominata/pathology* | - |
dc.title | Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Seo Hee Choi | - |
dc.contributor.googleauthor | Tae Min Jung | - |
dc.contributor.googleauthor | Ji E. Lee | - |
dc.contributor.googleauthor | Seung-Koo Lee | - |
dc.contributor.googleauthor | Young H. Sohn | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.identifier.doi | 21220177 | - |
dc.identifier.doi | 10.1016/j.neurobiolaging.2010.11.015 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A02912 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A03210 | - |
dc.relation.journalcode | J02322 | - |
dc.identifier.eissn | 1558-1497 | - |
dc.identifier.pmid | 21220177 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0197458010004987 | - |
dc.subject.keyword | Aged | - |
dc.subject.keyword | Cognition Disorders/pathology* | - |
dc.subject.keyword | Cognition Disorders/psychology* | - |
dc.subject.keyword | Cognitive Dysfunction/pathology | - |
dc.subject.keyword | Cognitive Dysfunction/psychology | - |
dc.subject.keyword | Female | - |
dc.subject.keyword | Humans | - |
dc.subject.keyword | Magnetic Resonance Imaging/methods* | - |
dc.subject.keyword | Male | - |
dc.subject.keyword | Middle Aged | - |
dc.subject.keyword | Organ Size | - |
dc.subject.keyword | Parkinson Disease/pathology* | - |
dc.subject.keyword | Parkinson Disease/psychology* | - |
dc.subject.keyword | Prospective Studies | - |
dc.subject.keyword | Substantia Innominata/pathology* | - |
dc.contributor.alternativeName | Sohn, Young Ho | - |
dc.contributor.alternativeName | Lee, Seung Koo | - |
dc.contributor.alternativeName | Lee, Ji Eun | - |
dc.contributor.alternativeName | Lee, Phil Hyu | - |
dc.contributor.affiliatedAuthor | Sohn, Young Ho | - |
dc.contributor.affiliatedAuthor | Lee, Seung Koo | - |
dc.contributor.affiliatedAuthor | Lee, Phil Hyu | - |
dc.contributor.affiliatedAuthor | Lee, Ji Eun | - |
dc.citation.volume | 33 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1265 | - |
dc.citation.endPage | 1272 | - |
dc.identifier.bibliographicCitation | NEUROBIOLOGY OF AGING, Vol.33(7) : 1265-1272, 2012 | - |
dc.identifier.rimsid | 31331 | - |
dc.type.rims | ART | - |
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