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Role of surface charge in cytotoxicity of charged manganese ferrite nanoparticles towards macrophages

Authors
 Seung-Hyun Yang  ;  Dan Heo  ;  Jinsung Park  ;  Sungsoo Na  ;  Jin-Suck Suh  ;  Seungjoo Haam  ;  Sahng Wook Park  ;  Yong-Min Huh  ;  Jaemoon Yang 
Citation
 NANOTECHNOLOGY, Vol.23(50) : 505702, 2012 
Journal Title
NANOTECHNOLOGY
ISSN
 0957-4484 
Issue Date
2012
MeSH
Animals ; Cell Line ; Cell Survival/drug effects ; Ferric Compounds/chemistry* ; Ferric Compounds/toxicity* ; Hydrophobic and Hydrophilic Interactions ; Ions/chemistry ; Ions/toxicity ; Macrophages/cytology ; Macrophages/drug effects* ; Manganese Compounds/chemistry* ; Mice ; Nanoparticles/chemistry* ; Nanoparticles/toxicity* ; Nanoparticles/ultrastructure ; Particle Size ; Polysorbates/chemistry ; Solubility ; Surface-Active Agents/chemistry
Keywords
Animals ; Cell Line ; Cell Survival/drug effects ; Ferric Compounds/chemistry* ; Ferric Compounds/toxicity* ; Hydrophobic and Hydrophilic Interactions ; Ions/chemistry ; Ions/toxicity ; Macrophages/cytology ; Macrophages/drug effects* ; Manganese Compounds/chemistry* ; Mice ; Nanoparticles/chemistry* ; Nanoparticles/toxicity* ; Nanoparticles/ultrastructure ; Particle Size ; Polysorbates/chemistry ; Solubility ; Surface-Active Agents/chemistry
Abstract
Amphiphilic surfactants have been used to disperse magnetic nanoparticles in biological media, because they exhibit a dual hydrophobic/hydrophilic affinity that facilitates the formation of a nanoemulsion, within which nanoparticle surfaces can be modified to achieve different physicochemical properties. For the investigation of the interactions of cells with charged magnetic nanoparticles in a biological medium, we selected the nanoemulsion method to prepare water-soluble magnetic nanoparticles using amphiphilic surfactant (polysorbate 80). The hydroxyl groups of polysorbate 80 were modified to carboxyl or amine groups. The chemical structures of carboxylated and aminated polysorbate 80 were confirmed, and water-soluble manganese ferrite nanoparticles (MFNPs) were synthesized with three types of polysorbate 80. Colloidal size, morphology, monodispersity, solubility and T2 relaxivity were found to be similar between the three types of MFNP. However, cationic MFNPs exhibited greater cytotoxicity in macrophages (RAW264.7 cells) and lower cellular membrane effective stiffness than anionic and non-ionic MFNPs. Moreover, cationic MFNPs exhibited large uptake efficiency for RAW264.7 cells compared with anionic or non-ionic MFNPs under the same conditions. Therefore, we propose that surface charge should be a key consideration factor in the design of magnetic nanoparticles for theragnostic applications.
Full Text
http://iopscience.iop.org/0957-4484/23/50/505702/
DOI
23164999
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Park, Sahng Wook(박상욱) ORCID logo https://orcid.org/0000-0002-9594-7074
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yang, Jae Moon(양재문) ORCID logo https://orcid.org/0000-0001-7365-0395
Huh, Yong Min(허용민) ORCID logo https://orcid.org/0000-0002-9831-4475
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91497
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