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Diffusion-weighted imaging versus superparamagnetic iron oxide (SPIO)-enhanced MRI: exclusive and combined values in the assessment of hepatic metastases

Authors
 Hana Kim  ;  Jeong-Sik Yu  ;  Eun-Suk Cho  ;  Jae-Joon Chung  ;  Joo Hee Kim  ;  Dae Jung Kim  ;  Jhii-Hyun Ahn  ;  Ki Whang Kim 
Citation
 MAGNETIC RESONANCE IMAGING, Vol.30(4) : 554-561, 2012 
Journal Title
MAGNETIC RESONANCE IMAGING
ISSN
 0730-725X 
Issue Date
2012
MeSH
Contrast Media* ; Dextrans* ; Diffusion Magnetic Resonance Imaging ; Female ; Humans ; Liver Neoplasms/secondary* ; Magnetic Resonance Imaging/methods* ; Magnetite Nanoparticles* ; Male ; Middle Aged ; ROC Curve ; Retrospective Studies ; Sensitivity and Specificity
Keywords
Diffusion-weighted MR imaging ; Iron oxide ; Liver ; MRLiver ; Neoplasms
Abstract
PURPOSE: The purpose was to validate diffusion-weighted imaging (DWI) in the assessment of hepatic metastases compared with superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging.

MATERIALS AND METHODS: For 21 consecutive patients with 160 metastases from extrahepatic malignancy and 25 benign focal lesions, two radiologists evaluated four separate review sessions (I, SPIO-enhanced T2-weighted images; II, precontrast DWI; III, SPIO-enhanced T2-weighted images and precontrast DWI; IV, SPIO-enhanced T2-weighted images plus precontrast and SPIO-enhanced DWI) and assigned confidence levels using a five-grade scale for each hepatic lesion.

RESULTS: The A(z) values after receiver operating characteristic curve analysis for Reader 1 and Reader 2 were 0.80 and 0.75 on session I, 0.91 and 0.91 on session II, 0.97 and 0.96 on session III and 0.96 and 0.96 on session IV, respectively. The A(z) value of session II was significantly higher than that of session I (Reader 1, P=.004; Reader 2, P<.001), and that of session III was significantly higher than that of session I (P<.001 for each reader) or session II (Reader 1, P=.004; Reader 2, P=.003). Although there was no significant difference of A(z) value between session III and session IV (Reader 1, P=.231; Reader 2, P=.878), the sensitivity improved for session IV compared with that for session III (Reader 1, P=.031; Reader 2, P=.039).

CONCLUSION: In the assessment of hepatic metastases, DWI can provide more accurate information than can SPIO-enhanced images. Diagnostic accuracy can be increased even more through the combination of both techniques.
Full Text
http://www.sciencedirect.com/science/article/pii/S0730725X11004693
DOI
10.1016/j.mri.2011.12.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Whang(김기황)
Kim, Dae Jung(김대중)
Kim, Joo Hee(김주희) ORCID logo https://orcid.org/0000-0001-5383-3602
Kim, Ha Na(김하나)
Ahn, Jhii Hyun(안지현)
Yu, Jeong Sik(유정식) ORCID logo https://orcid.org/0000-0002-8171-5838
Chung, Jae Joon(정재준) ORCID logo https://orcid.org/0000-0002-7447-1193
Cho, Eun Suk(조은석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91431
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