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The significance of ICG-R15 in predicting hepatic toxicity in patients receiving radiotherapy for hepatocellular carcinoma.

 Hong In Yoon  ;  Woong Sub Koom  ;  Ik Jae Lee  ;  Kyoungkeun Jeong  ;  Yoonsun Chung  ;  Ja Kyung Kim  ;  Kwan Sik Lee  ;  Kwang-Hyub Han  ;  Jinsil Seong 
 Liver International, Vol.32(7) : 1165-1171, 2012 
Journal Title
 Liver International 
Issue Date
AIM: To evaluate whether the retention rate of indocyanine green 15 min after administration (ICG-R15) could predict radiation hepatotoxicity in patients treated with radiotherapy (RT) for hepatocellular carcinoma (HCC). METHODS: We retrospectively reviewed data of 146 HCC patients treated with RT between February 1994 and December 2008. The ICG-R15 was measured within 1 month prior to the start of RT. Radiation hepatotoxicity was evaluated by incidence of radiation-induced liver disease (RILD) between 2 weeks and 3 months after completion of RT. We analysed the correlation between the incidence rate of RILD and the ICG-R15 before RT (pre-RT ICG-R15). RESULTS: The classic and non-classic RILD occurred in 15 patients (10.3%): classic type in five patients (3.4%) and non-classic RILD in 10 patients (6.9%). A positive correlation was shown between the probability of RILD and increase in pre-RT ICG-R15 (P < 0.0001). Univariate analysis indicated that cut-off value of pre-RT ICG-R15 could predict RILD significantly. The incidence of RILD for the patients with 22% or higher pre-RT ICG-R15 levels was 40.7% as compared to 3.4% for those with levels lower than 22% (P < 0.0001). There was no clinical factor that significantly affected RILD in univariate analysis. Multivariate analysis indicated that the pre-RT ICG-R15 value was the only significant factor affecting RILD (P < 0.0001). CONCLUSION: These results suggest that pre-RT ICG-R15 could be a useful factor in predicting radiation hepatotoxicity in HCC patients treated with RT.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
금웅섭(Koom, Woong Sub) ; 김자경(Kim, Ja Kyung) ; 성진실(Seong, Jin Sil) ; 윤홍인(Yoon, Hong In) ; 이관식(Lee, Kwan Sik) ; 이익재(Lee, Ik Jae) ; 정경근(Jeong, Kyoung Keun) ; 정윤선(Chung, Yoon Sun) ; 한광협(Han, Kwang Hyup)
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