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The significance of ICG-R15 in predicting hepatic toxicity in patients receiving radiotherapy for hepatocellular carcinoma.

 Hong In Yoon  ;  Woong Sub Koom  ;  Ik Jae Lee  ;  Kyoungkeun Jeong  ;  Yoonsun Chung  ;  Ja Kyung Kim  ;  Kwan Sik Lee  ;  Kwang-Hyub Han  ;  Jinsil Seong 
 LIVER INTERNATIONAL, Vol.32(7) : 1165-1171, 2012 
Journal Title
Issue Date
Aged ; Carcinoma, Hepatocellular/radiotherapy* ; Coloring Agents* ; Female ; Humans ; Indocyanine Green* ; Liver Diseases/etiology ; Liver Neoplasms/radiotherapy* ; Male ; Middle Aged ; Radiation Injuries/etiology ; Radiotherapy/adverse effects* ; Retrospective Studies
hepatocellular carcinoma ; ICG-R15 ; radiation-induced liver disease ; radiotherapy ; toxicity
AIM: To evaluate whether the retention rate of indocyanine green 15 min after administration (ICG-R15) could predict radiation hepatotoxicity in patients treated with radiotherapy (RT) for hepatocellular carcinoma (HCC). METHODS: We retrospectively reviewed data of 146 HCC patients treated with RT between February 1994 and December 2008. The ICG-R15 was measured within 1 month prior to the start of RT. Radiation hepatotoxicity was evaluated by incidence of radiation-induced liver disease (RILD) between 2 weeks and 3 months after completion of RT. We analysed the correlation between the incidence rate of RILD and the ICG-R15 before RT (pre-RT ICG-R15). RESULTS: The classic and non-classic RILD occurred in 15 patients (10.3%): classic type in five patients (3.4%) and non-classic RILD in 10 patients (6.9%). A positive correlation was shown between the probability of RILD and increase in pre-RT ICG-R15 (P < 0.0001). Univariate analysis indicated that cut-off value of pre-RT ICG-R15 could predict RILD significantly. The incidence of RILD for the patients with 22% or higher pre-RT ICG-R15 levels was 40.7% as compared to 3.4% for those with levels lower than 22% (P < 0.0001). There was no clinical factor that significantly affected RILD in univariate analysis. Multivariate analysis indicated that the pre-RT ICG-R15 value was the only significant factor affecting RILD (P < 0.0001). CONCLUSION: These results suggest that pre-RT ICG-R15 could be a useful factor in predicting radiation hepatotoxicity in HCC patients treated with RT.
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1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Koom, Woong Sub(금웅섭) ORCID logo https://orcid.org/0000-0002-9435-7750
Kim, Ja Kyung(김자경) ORCID logo https://orcid.org/0000-0001-5025-6846
Seong, Jin Sil(성진실) ORCID logo https://orcid.org/0000-0003-1794-5951
Yoon, Hong In(윤홍인) ORCID logo https://orcid.org/0000-0002-2106-6856
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Lee, Ik Jae(이익재) ORCID logo https://orcid.org/0000-0001-7165-3373
Jeong, Kyoung Keun(정경근)
Chung, Yoon Sun(정윤선)
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
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