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The significance of ICG-R15 in predicting hepatic toxicity in patients receiving radiotherapy for hepatocellular carcinoma.

DC FieldValueLanguage
dc.contributor.author금웅섭-
dc.contributor.author김자경-
dc.contributor.author성진실-
dc.contributor.author윤홍인-
dc.contributor.author이관식-
dc.contributor.author이익재-
dc.contributor.author정경근-
dc.contributor.author정윤선-
dc.contributor.author한광협-
dc.date.accessioned2014-12-19T17:26:26Z-
dc.date.available2014-12-19T17:26:26Z-
dc.date.issued2012-
dc.identifier.issn1478-3223-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91412-
dc.description.abstractAIM: To evaluate whether the retention rate of indocyanine green 15 min after administration (ICG-R15) could predict radiation hepatotoxicity in patients treated with radiotherapy (RT) for hepatocellular carcinoma (HCC). METHODS: We retrospectively reviewed data of 146 HCC patients treated with RT between February 1994 and December 2008. The ICG-R15 was measured within 1 month prior to the start of RT. Radiation hepatotoxicity was evaluated by incidence of radiation-induced liver disease (RILD) between 2 weeks and 3 months after completion of RT. We analysed the correlation between the incidence rate of RILD and the ICG-R15 before RT (pre-RT ICG-R15). RESULTS: The classic and non-classic RILD occurred in 15 patients (10.3%): classic type in five patients (3.4%) and non-classic RILD in 10 patients (6.9%). A positive correlation was shown between the probability of RILD and increase in pre-RT ICG-R15 (P < 0.0001). Univariate analysis indicated that cut-off value of pre-RT ICG-R15 could predict RILD significantly. The incidence of RILD for the patients with 22% or higher pre-RT ICG-R15 levels was 40.7% as compared to 3.4% for those with levels lower than 22% (P < 0.0001). There was no clinical factor that significantly affected RILD in univariate analysis. Multivariate analysis indicated that the pre-RT ICG-R15 value was the only significant factor affecting RILD (P < 0.0001). CONCLUSION: These results suggest that pre-RT ICG-R15 could be a useful factor in predicting radiation hepatotoxicity in HCC patients treated with RT.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfLiver International-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe significance of ICG-R15 in predicting hepatic toxicity in patients receiving radiotherapy for hepatocellular carcinoma.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학)-
dc.contributor.googleauthorHong In Yoon-
dc.contributor.googleauthorWoong Sub Koom-
dc.contributor.googleauthorIk Jae Lee-
dc.contributor.googleauthorKyoungkeun Jeong-
dc.contributor.googleauthorYoonsun Chung-
dc.contributor.googleauthorJa Kyung Kim-
dc.contributor.googleauthorKwan Sik Lee-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorJinsil Seong-
dc.identifier.doi10.1111/j.1478-3231.2012.02784.x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00273-
dc.contributor.localIdA00852-
dc.contributor.localIdA01956-
dc.contributor.localIdA02666-
dc.contributor.localIdA03055-
dc.contributor.localIdA03569-
dc.contributor.localIdA03678-
dc.contributor.localIdA04268-
dc.contributor.localIdA04777-
dc.relation.journalcodeJ02171-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2012.02784.x/abstract-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.alternativeNameKim, Ja Kyung-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameYoon, Hong In-
dc.contributor.alternativeNameLee, Kwan Sik-
dc.contributor.alternativeNameLee, Ik Jae-
dc.contributor.alternativeNameJeong, Kyoung Keun-
dc.contributor.alternativeNameChung, Yoon Sun-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKoom, Woong Sub-
dc.contributor.affiliatedAuthorKim, Ja Kyung-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorLee, Kwan Sik-
dc.contributor.affiliatedAuthorLee, Ik Jae-
dc.contributor.affiliatedAuthorJeong, Kyoung Keun-
dc.contributor.affiliatedAuthorChung, Yoon Sun-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorYoon, Hong In-
dc.citation.volume32-
dc.citation.number7-
dc.citation.startPage1165-
dc.citation.endPage1171-
dc.identifier.bibliographicCitationLiver International, Vol.32(7) : 1165-1171, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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