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Novel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: a proof-of-concept study.

Authors
 Jung-Chul Park  ;  Jong-Bin Lee  ;  Guy Daculsi  ;  Sang-Yeop Oh  ;  Kyoo-Sung Cho  ;  Gun-Il Im  ;  Byung-Soo Kim  ;  Chang-Sung Kim 
Citation
 JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.42(4) : 136-143, 2012 
Journal Title
 JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE 
ISSN
 2093-2278 
Issue Date
2012
Keywords
Animals ; Dental implants ; Osseointegration
Abstract
PURPOSE: The osseointegration around titanium mini-implants installed in macroporous biphasic calcium phosphate (MBCP) blocks was evaluated after incubation with recombinant human bone morphogenetic protein-2 (rhBMP-2) in an ectopic subcutaneous rat model. METHODS: Mini-implants (φ1.8×12 mm) were installed in MBCP blocks (bMBCPs, 4×5×15 mm) loaded with rhBMP-2 at 0.1 mg/mL, and then implanted for 8 weeks into subcutaneous pockets of male Sprague-Dawley rats (n=10). A histomorphometric analysis was performed, and the bone-to-implant contact (BIC) and bone density were evaluated. RESULTS: Significant osteoinductive activity was induced in the rhBMP-2/bMBCP group. The percentage of BIC was 41.23±4.13% (mean±standard deviation), while bone density was 33.47±5.73%. In contrast, no bone formation was observed in the bMBCP only group. CONCLUSIONS: This model represents a more standardized tool for analyzing osseointegration and bone healing along the implant surface and in bMBCPs that excludes various healing factors derived from selected animals and defect models.
Files in This Item:
T201203452.pdf Download
DOI
10.5051/jpis.2012.42.4.136
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Park, Jung Chul(박정철)
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91050
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