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Novel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: a proof-of-concept study.

DC FieldValueLanguage
dc.contributor.author김창성-
dc.contributor.author박정철-
dc.contributor.author조규성-
dc.date.accessioned2014-12-19T17:14:43Z-
dc.date.available2014-12-19T17:14:43Z-
dc.date.issued2012-
dc.identifier.issn2093-2278-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91050-
dc.description.abstractPURPOSE: The osseointegration around titanium mini-implants installed in macroporous biphasic calcium phosphate (MBCP) blocks was evaluated after incubation with recombinant human bone morphogenetic protein-2 (rhBMP-2) in an ectopic subcutaneous rat model. METHODS: Mini-implants (φ1.8×12 mm) were installed in MBCP blocks (bMBCPs, 4×5×15 mm) loaded with rhBMP-2 at 0.1 mg/mL, and then implanted for 8 weeks into subcutaneous pockets of male Sprague-Dawley rats (n=10). A histomorphometric analysis was performed, and the bone-to-implant contact (BIC) and bone density were evaluated. RESULTS: Significant osteoinductive activity was induced in the rhBMP-2/bMBCP group. The percentage of BIC was 41.23±4.13% (mean±standard deviation), while bone density was 33.47±5.73%. In contrast, no bone formation was observed in the bMBCP only group. CONCLUSIONS: This model represents a more standardized tool for analyzing osseointegration and bone healing along the implant surface and in bMBCPs that excludes various healing factors derived from selected animals and defect models.-
dc.description.statementOfResponsibilityopen-
dc.format.extent136~143-
dc.relation.isPartOfJOURNAL OF PERIODONTAL AND IMPLANT SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleNovel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: a proof-of-concept study.-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Periodontology (치주과학)-
dc.contributor.googleauthorJung-Chul Park-
dc.contributor.googleauthorJong-Bin Lee-
dc.contributor.googleauthorGuy Daculsi-
dc.contributor.googleauthorSang-Yeop Oh-
dc.contributor.googleauthorKyoo-Sung Cho-
dc.contributor.googleauthorGun-Il Im-
dc.contributor.googleauthorByung-Soo Kim-
dc.contributor.googleauthorChang-Sung Kim-
dc.identifier.doi10.5051/jpis.2012.42.4.136-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01041-
dc.contributor.localIdA01653-
dc.contributor.localIdA03810-
dc.relation.journalcodeJ01695-
dc.identifier.eissn2093-2286-
dc.identifier.pmidAnimals ; Dental implants ; Osseointegration-
dc.subject.keywordAnimals-
dc.subject.keywordDental implants-
dc.subject.keywordOsseointegration-
dc.contributor.alternativeNameKim, Chang Sung-
dc.contributor.alternativeNamePark, Jung Chul-
dc.contributor.alternativeNameCho, Kyoo Sung-
dc.contributor.affiliatedAuthorKim, Chang Sung-
dc.contributor.affiliatedAuthorPark, Jung Chul-
dc.contributor.affiliatedAuthorCho, Kyoo Sung-
dc.citation.volume42-
dc.citation.number4-
dc.citation.startPage136-
dc.citation.endPage143-
dc.identifier.bibliographicCitationJOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.42(4) : 136-143, 2012-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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