Cited 6 times in
Novel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: a proof-of-concept study.
DC Field | Value | Language |
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dc.contributor.author | 김창성 | - |
dc.contributor.author | 박정철 | - |
dc.contributor.author | 조규성 | - |
dc.date.accessioned | 2014-12-19T17:14:43Z | - |
dc.date.available | 2014-12-19T17:14:43Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 2093-2278 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91050 | - |
dc.description.abstract | PURPOSE: The osseointegration around titanium mini-implants installed in macroporous biphasic calcium phosphate (MBCP) blocks was evaluated after incubation with recombinant human bone morphogenetic protein-2 (rhBMP-2) in an ectopic subcutaneous rat model. METHODS: Mini-implants (φ1.8×12 mm) were installed in MBCP blocks (bMBCPs, 4×5×15 mm) loaded with rhBMP-2 at 0.1 mg/mL, and then implanted for 8 weeks into subcutaneous pockets of male Sprague-Dawley rats (n=10). A histomorphometric analysis was performed, and the bone-to-implant contact (BIC) and bone density were evaluated. RESULTS: Significant osteoinductive activity was induced in the rhBMP-2/bMBCP group. The percentage of BIC was 41.23±4.13% (mean±standard deviation), while bone density was 33.47±5.73%. In contrast, no bone formation was observed in the bMBCP only group. CONCLUSIONS: This model represents a more standardized tool for analyzing osseointegration and bone healing along the implant surface and in bMBCPs that excludes various healing factors derived from selected animals and defect models. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 136~143 | - |
dc.relation.isPartOf | JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Novel analysis model for implant osseointegration using ectopic bone formation via the recombinant human bone morphogenetic protein-2/macroporous biphasic calcium phosphate block system in rats: a proof-of-concept study. | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Periodontology (치주과학) | - |
dc.contributor.googleauthor | Jung-Chul Park | - |
dc.contributor.googleauthor | Jong-Bin Lee | - |
dc.contributor.googleauthor | Guy Daculsi | - |
dc.contributor.googleauthor | Sang-Yeop Oh | - |
dc.contributor.googleauthor | Kyoo-Sung Cho | - |
dc.contributor.googleauthor | Gun-Il Im | - |
dc.contributor.googleauthor | Byung-Soo Kim | - |
dc.contributor.googleauthor | Chang-Sung Kim | - |
dc.identifier.doi | 10.5051/jpis.2012.42.4.136 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01041 | - |
dc.contributor.localId | A01653 | - |
dc.contributor.localId | A03810 | - |
dc.relation.journalcode | J01695 | - |
dc.identifier.eissn | 2093-2286 | - |
dc.identifier.pmid | Animals ; Dental implants ; Osseointegration | - |
dc.subject.keyword | Animals | - |
dc.subject.keyword | Dental implants | - |
dc.subject.keyword | Osseointegration | - |
dc.contributor.alternativeName | Kim, Chang Sung | - |
dc.contributor.alternativeName | Park, Jung Chul | - |
dc.contributor.alternativeName | Cho, Kyoo Sung | - |
dc.contributor.affiliatedAuthor | Kim, Chang Sung | - |
dc.contributor.affiliatedAuthor | Park, Jung Chul | - |
dc.contributor.affiliatedAuthor | Cho, Kyoo Sung | - |
dc.citation.volume | 42 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 136 | - |
dc.citation.endPage | 143 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.42(4) : 136-143, 2012 | - |
dc.identifier.rimsid | 33302 | - |
dc.type.rims | ART | - |
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