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Licochalcone E has an antidiabetic effect

Authors
 Hong Gyu Park  ;  Eun Jung Bak  ;  Gye-Hyeong Woo  ;  Jin Moon Kim  ;  Zhejiu Quan  ;  Jung Mogg Kim  ;  Ho-Kun Yoon  ;  Seung Hoon Cheon  ;  Goo Yoon  ;  Yun-Jung Yoo  ;  Younghwa Na  ;  Jeong-Heon Cha 
Citation
 JOURNAL OF NUTRITIONAL BIOCHEMISTRY, Vol.23(7) : 759-767, 2012 
Journal Title
 JOURNAL OF NUTRITIONAL BIOCHEMISTRY 
ISSN
 0955-2863 
Issue Date
2012
MeSH
3T3-L1 Cells ; Adipocytes/cytology ; Adipocytes/drug effects* ; Adipocytes/metabolism ; Adipogenesis/physiology ; Adipose Tissue, White/drug effects ; Adipose Tissue, White/metabolism ; Animals ; Cell Differentiation ; Chalcones/pharmacology* ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/physiopathology* ; Glycyrrhiza/chemistry ; Hypoglycemic Agents/pharmacology* ; Male ; Mice ; Mice, Inbred C57BL ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Plant Extracts/pharmacology* ; Plant Roots/chemistry ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction ; Triglycerides/blood
Keywords
Licochalcone E ; Adipocyte differentiation ; Obesity ; Diabetes
Abstract
Licochalcone E (lico E) is a retrochalcone isolated from the root of Glycyrrhiza inflata. Retrochalcone compounds evidence a variety of pharmacological profiles, including anticancer, antiparasitic, antibacterial, antioxidative and superoxide-scavenging properties. In this study, we evaluated the biological effects of lico E on adipocyte differentiation in vitro and obesity-related diabetes in vivo. We employed 3T3-L1 preadipocyte and C3H10T1/2 stem cells for in vitro adipocyte differentiation study and diet-induced diabetic mice for in vivo study. The presence of lico E during adipogenesis induced adipocyte differentiation to a significant degree, particularly at the early induction stage. Licochalcone E evidenced weak, but significant, peroxisome proliferator-activated receptor gamma (PPARγ) ligand-binding activity. Two weeks of lico E treatment lowered blood glucose levels and serum triglyceride levels in the diabetic mice. Additionally, treatment with lico E resulted in marked reductions in adipocyte size and increases in the mRNA expression levels of PPARγ in white adipose tissue (WAT). Licochalcone E was also shown to significantly stimulate Akt signaling in epididymal WAT. In conclusion, lico E increases the levels of PPARγ expression, at least in part, via the stimulation of Akt signals and functions as a PPARγ partial agonist, and this increased PPARγ expression enhances adipocyte differentiation and increases the population of small adipocytes, resulting in improvements in hyperglycemia and hyperlipidemia under diabetic conditions.
Full Text
http://www.sciencedirect.com/science/article/pii/S0955286311001252
DOI
21840191
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers
Yonsei Authors
Kim, Jin Moon(김진문)
Bak, Eun-Jung(박은정) ORCID logo https://orcid.org/0000-0002-7976-8594
Park, Hong Gyu(박홍규)
Yoo, Yun Jung(유윤정) ORCID logo https://orcid.org/0000-0002-0045-9597
Yoon, Ho Geun(윤호근) ORCID logo https://orcid.org/0000-0003-2718-3372
Quan, Zhejiu(전철구)
Cha, Jung Heon(차정헌) ORCID logo https://orcid.org/0000-0002-9385-2653
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/91017
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