Cited 54 times in

Licochalcone E has an antidiabetic effect

DC Field Value Language
dc.contributor.author박홍규-
dc.contributor.author유윤정-
dc.contributor.author윤호근-
dc.contributor.author전철구-
dc.contributor.author차정헌-
dc.contributor.author김진문-
dc.contributor.author박은정-
dc.date.accessioned2014-12-19T17:13:41Z-
dc.date.available2014-12-19T17:13:41Z-
dc.date.issued2012-
dc.identifier.issn0955-2863-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/91017-
dc.description.abstractLicochalcone E (lico E) is a retrochalcone isolated from the root of Glycyrrhiza inflata. Retrochalcone compounds evidence a variety of pharmacological profiles, including anticancer, antiparasitic, antibacterial, antioxidative and superoxide-scavenging properties. In this study, we evaluated the biological effects of lico E on adipocyte differentiation in vitro and obesity-related diabetes in vivo. We employed 3T3-L1 preadipocyte and C3H10T1/2 stem cells for in vitro adipocyte differentiation study and diet-induced diabetic mice for in vivo study. The presence of lico E during adipogenesis induced adipocyte differentiation to a significant degree, particularly at the early induction stage. Licochalcone E evidenced weak, but significant, peroxisome proliferator-activated receptor gamma (PPARγ) ligand-binding activity. Two weeks of lico E treatment lowered blood glucose levels and serum triglyceride levels in the diabetic mice. Additionally, treatment with lico E resulted in marked reductions in adipocyte size and increases in the mRNA expression levels of PPARγ in white adipose tissue (WAT). Licochalcone E was also shown to significantly stimulate Akt signaling in epididymal WAT. In conclusion, lico E increases the levels of PPARγ expression, at least in part, via the stimulation of Akt signals and functions as a PPARγ partial agonist, and this increased PPARγ expression enhances adipocyte differentiation and increases the population of small adipocytes, resulting in improvements in hyperglycemia and hyperlipidemia under diabetic conditions.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF NUTRITIONAL BIOCHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESH3T3-L1 Cells-
dc.subject.MESHAdipocytes/cytology-
dc.subject.MESHAdipocytes/drug effects*-
dc.subject.MESHAdipocytes/metabolism-
dc.subject.MESHAdipogenesis/physiology-
dc.subject.MESHAdipose Tissue, White/drug effects-
dc.subject.MESHAdipose Tissue, White/metabolism-
dc.subject.MESHAnimals-
dc.subject.MESHCell Differentiation-
dc.subject.MESHChalcones/pharmacology*-
dc.subject.MESHDiabetes Mellitus/drug therapy-
dc.subject.MESHDiabetes Mellitus/physiopathology*-
dc.subject.MESHGlycyrrhiza/chemistry-
dc.subject.MESHHypoglycemic Agents/pharmacology*-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHPPAR gamma/genetics-
dc.subject.MESHPPAR gamma/metabolism-
dc.subject.MESHPlant Extracts/pharmacology*-
dc.subject.MESHPlant Roots/chemistry-
dc.subject.MESHProto-Oncogene Proteins c-akt/genetics-
dc.subject.MESHProto-Oncogene Proteins c-akt/metabolism-
dc.subject.MESHRNA, Messenger/genetics-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHSignal Transduction-
dc.subject.MESHTriglycerides/blood-
dc.titleLicochalcone E has an antidiabetic effect-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학)-
dc.contributor.googleauthorHong Gyu Park-
dc.contributor.googleauthorEun Jung Bak-
dc.contributor.googleauthorGye-Hyeong Woo-
dc.contributor.googleauthorJin Moon Kim-
dc.contributor.googleauthorZhejiu Quan-
dc.contributor.googleauthorJung Mogg Kim-
dc.contributor.googleauthorHo-Kun Yoon-
dc.contributor.googleauthorSeung Hoon Cheon-
dc.contributor.googleauthorGoo Yoon-
dc.contributor.googleauthorYun-Jung Yoo-
dc.contributor.googleauthorYounghwa Na-
dc.contributor.googleauthorJeong-Heon Cha-
dc.identifier.doi10.1016/j.jnutbio.2011.03.021-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01771-
dc.contributor.localIdA02490-
dc.contributor.localIdA02625-
dc.contributor.localIdA03555-
dc.contributor.localIdA04007-
dc.contributor.localIdA01014-
dc.contributor.localIdA01614-
dc.relation.journalcodeJ01650-
dc.identifier.eissn1873-4847-
dc.identifier.pmid21840191-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0955286311001252-
dc.subject.keywordLicochalcone E-
dc.subject.keywordAdipocyte differentiation-
dc.subject.keywordObesity-
dc.subject.keywordDiabetes-
dc.contributor.alternativeNamePark, Hong Gyu-
dc.contributor.alternativeNameYoo, Yun Jung-
dc.contributor.alternativeNameYoon, Ho Geun-
dc.contributor.alternativeNameQuan, Zhejiu-
dc.contributor.alternativeNameCha, Jung Heon-
dc.contributor.alternativeNameKim, Jin Moon-
dc.contributor.alternativeNameBak, Eun-Jung-
dc.contributor.affiliatedAuthorPark, Hong Gyu-
dc.contributor.affiliatedAuthorYoo, Yun Jung-
dc.contributor.affiliatedAuthorYoon, Ho Geun-
dc.contributor.affiliatedAuthorQuan, Zhejiu-
dc.contributor.affiliatedAuthorCha, Jung Heon-
dc.contributor.affiliatedAuthorKim, Jin Moon-
dc.contributor.affiliatedAuthorBak, Eun-Jung-
dc.citation.volume23-
dc.citation.number7-
dc.citation.startPage759-
dc.citation.endPage767-
dc.identifier.bibliographicCitationJOURNAL OF NUTRITIONAL BIOCHEMISTRY, Vol.23(7) : 759-767, 2012-
dc.identifier.rimsid33277-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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