Cited 54 times in
Licochalcone E has an antidiabetic effect
DC Field | Value | Language |
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dc.contributor.author | 박홍규 | - |
dc.contributor.author | 유윤정 | - |
dc.contributor.author | 윤호근 | - |
dc.contributor.author | 전철구 | - |
dc.contributor.author | 차정헌 | - |
dc.contributor.author | 김진문 | - |
dc.contributor.author | 박은정 | - |
dc.date.accessioned | 2014-12-19T17:13:41Z | - |
dc.date.available | 2014-12-19T17:13:41Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0955-2863 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/91017 | - |
dc.description.abstract | Licochalcone E (lico E) is a retrochalcone isolated from the root of Glycyrrhiza inflata. Retrochalcone compounds evidence a variety of pharmacological profiles, including anticancer, antiparasitic, antibacterial, antioxidative and superoxide-scavenging properties. In this study, we evaluated the biological effects of lico E on adipocyte differentiation in vitro and obesity-related diabetes in vivo. We employed 3T3-L1 preadipocyte and C3H10T1/2 stem cells for in vitro adipocyte differentiation study and diet-induced diabetic mice for in vivo study. The presence of lico E during adipogenesis induced adipocyte differentiation to a significant degree, particularly at the early induction stage. Licochalcone E evidenced weak, but significant, peroxisome proliferator-activated receptor gamma (PPARγ) ligand-binding activity. Two weeks of lico E treatment lowered blood glucose levels and serum triglyceride levels in the diabetic mice. Additionally, treatment with lico E resulted in marked reductions in adipocyte size and increases in the mRNA expression levels of PPARγ in white adipose tissue (WAT). Licochalcone E was also shown to significantly stimulate Akt signaling in epididymal WAT. In conclusion, lico E increases the levels of PPARγ expression, at least in part, via the stimulation of Akt signals and functions as a PPARγ partial agonist, and this increased PPARγ expression enhances adipocyte differentiation and increases the population of small adipocytes, resulting in improvements in hyperglycemia and hyperlipidemia under diabetic conditions. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF NUTRITIONAL BIOCHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 3T3-L1 Cells | - |
dc.subject.MESH | Adipocytes/cytology | - |
dc.subject.MESH | Adipocytes/drug effects* | - |
dc.subject.MESH | Adipocytes/metabolism | - |
dc.subject.MESH | Adipogenesis/physiology | - |
dc.subject.MESH | Adipose Tissue, White/drug effects | - |
dc.subject.MESH | Adipose Tissue, White/metabolism | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Chalcones/pharmacology* | - |
dc.subject.MESH | Diabetes Mellitus/drug therapy | - |
dc.subject.MESH | Diabetes Mellitus/physiopathology* | - |
dc.subject.MESH | Glycyrrhiza/chemistry | - |
dc.subject.MESH | Hypoglycemic Agents/pharmacology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | PPAR gamma/genetics | - |
dc.subject.MESH | PPAR gamma/metabolism | - |
dc.subject.MESH | Plant Extracts/pharmacology* | - |
dc.subject.MESH | Plant Roots/chemistry | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt/metabolism | - |
dc.subject.MESH | RNA, Messenger/genetics | - |
dc.subject.MESH | RNA, Messenger/metabolism | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Triglycerides/blood | - |
dc.title | Licochalcone E has an antidiabetic effect | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Hong Gyu Park | - |
dc.contributor.googleauthor | Eun Jung Bak | - |
dc.contributor.googleauthor | Gye-Hyeong Woo | - |
dc.contributor.googleauthor | Jin Moon Kim | - |
dc.contributor.googleauthor | Zhejiu Quan | - |
dc.contributor.googleauthor | Jung Mogg Kim | - |
dc.contributor.googleauthor | Ho-Kun Yoon | - |
dc.contributor.googleauthor | Seung Hoon Cheon | - |
dc.contributor.googleauthor | Goo Yoon | - |
dc.contributor.googleauthor | Yun-Jung Yoo | - |
dc.contributor.googleauthor | Younghwa Na | - |
dc.contributor.googleauthor | Jeong-Heon Cha | - |
dc.identifier.doi | 10.1016/j.jnutbio.2011.03.021 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01771 | - |
dc.contributor.localId | A02490 | - |
dc.contributor.localId | A02625 | - |
dc.contributor.localId | A03555 | - |
dc.contributor.localId | A04007 | - |
dc.contributor.localId | A01014 | - |
dc.contributor.localId | A01614 | - |
dc.relation.journalcode | J01650 | - |
dc.identifier.eissn | 1873-4847 | - |
dc.identifier.pmid | 21840191 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0955286311001252 | - |
dc.subject.keyword | Licochalcone E | - |
dc.subject.keyword | Adipocyte differentiation | - |
dc.subject.keyword | Obesity | - |
dc.subject.keyword | Diabetes | - |
dc.contributor.alternativeName | Park, Hong Gyu | - |
dc.contributor.alternativeName | Yoo, Yun Jung | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.alternativeName | Quan, Zhejiu | - |
dc.contributor.alternativeName | Cha, Jung Heon | - |
dc.contributor.alternativeName | Kim, Jin Moon | - |
dc.contributor.alternativeName | Bak, Eun-Jung | - |
dc.contributor.affiliatedAuthor | Park, Hong Gyu | - |
dc.contributor.affiliatedAuthor | Yoo, Yun Jung | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Quan, Zhejiu | - |
dc.contributor.affiliatedAuthor | Cha, Jung Heon | - |
dc.contributor.affiliatedAuthor | Kim, Jin Moon | - |
dc.contributor.affiliatedAuthor | Bak, Eun-Jung | - |
dc.citation.volume | 23 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 759 | - |
dc.citation.endPage | 767 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUTRITIONAL BIOCHEMISTRY, Vol.23(7) : 759-767, 2012 | - |
dc.identifier.rimsid | 33277 | - |
dc.type.rims | ART | - |
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