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Magnetic resonance imaging targeted biopsy in men with previously negative prostate biopsy results

Authors
 Seung Hwan Lee  ;  Mun Su Chung  ;  Joo Hee Kim  ;  Young Taik Oh  ;  Koon Ho Rha  ;  Byung Ha Chung 
Citation
 Journal of Endourology, Vol.26(7) : 787-791, 2012 
Journal Title
 Journal of Endourology 
ISSN
 0892-7790 
Issue Date
2012
MeSH
Aged ; Aged, 80 and over ; Biopsy ; Humans ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Prostate/pathology* ; Prostate-Specific Antigen/blood ; Prostatectomy ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/pathology* ; Prostatic Neoplasms/surgery ; Reproducibility of Results
Keywords
Aged ; Aged, 80 and over ; Biopsy ; Humans ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Prostate/pathology* ; Prostate-Specific Antigen/blood ; Prostatectomy ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/pathology* ; Prostatic Neoplasms/surgery ; Reproducibility of Results
Abstract
PURPOSE: To evaluate the efficacy of targeted prostate biopsy using magnetic resonance imaging (MRI) and to characterize clinicopathologic features of tumors detected with targeted prostate biopsy in men with previous negative prostate biopsy results. PATIENTS AND METHODS: We prospectively studied 87 patients with a persistently increasing level of serum prostate-specific antigen (PSA), at least one previous set of negative 12-core prostate biopsies, and normal digital rectal examination. All patients were examined with combined T2-weighted and diffusion-weighted MRI before undergoing the prostate biopsy. Prostate biopsy was performed using transrectal ultrasonography-guided standard 12 cores plus targeted biopsy to suspicious region(s) as identified on T2 images on their MRI. RESULTS: Of a total of 87 cases, 82 (94.2%) patients had suspicious lesion(s) on their MRI. Of these 82 patients, 46 (56.0%) patients had prostate cancer (PCA) as determined by the biopsy. The patients with PCA showed a significantly higher incidence of having suspicious lesion(s) (the anterior or apex) on MRI than the patients without PCA (P<0.05). On analysis by dividing all biopsy cores into the targeted cores and standard cores, PCA was found in 149/518 (28.8%) MRI-targeted cores and in 32/903 (3.6%) standard cores (P=0.012) Of 43 patients who underwent radical prostatectomy, 37 (86.0%) patients were detected with PCA located at the anterior or apex portion of the prostate. For tumor characteristics according to tumor locations, there was no significant correlation between tumor location and Gleason scores or pathologic stage. CONCLUSIONS: Our data suggest that a MRI-targeted prostate biopsy after prostate MRI might be considered for the identification of cancer foci and the detection of PCA, for patients with a previous negative standard prostate biopsy result despite a persistently elevated PSA value.
Full Text
http://online.liebertpub.com/doi/abs/10.1089/end.2011.0393
DOI
22122555
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hee(김주희) ORCID logo https://orcid.org/0000-0001-5383-3602
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
Lee, Seung Hwan(이승환) ORCID logo https://orcid.org/0000-0001-7358-8544
Chung, Mun Su(정문수)
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90785
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