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The clinical effect of locally delivered minocycline in association with flap surgery for the treatment of chronic severe periodontitis: a split-mouth design

Authors
 Dong-Yeol Jung  ;  Jung-Chul Park  ;  Young-Taek Kim  ;  Je-Young Yon  ;  Gun-Il Im  ;  Byung-Soo Kim  ;  Seong-Ho Choi  ;  Kyoo-Sung Cho  ;  Chang-Sung Kim 
Citation
 JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.39(8) : 753-759, 2012 
Journal Title
 JOURNAL OF CLINICAL PERIODONTOLOGY 
ISSN
 0303-6979 
Issue Date
2012
MeSH
Administration, Topical ; Adult ; Aged ; Anti-Bacterial Agents/administration & dosage* ; Chronic Periodontitis/drug therapy ; Chronic Periodontitis/surgery* ; Combined Modality Therapy ; Dental Plaque Index ; Female ; Follow-Up Studies ; Gingival Hemorrhage/drug therapy ; Gingival Hemorrhage/surgery ; Gingival Recession/drug therapy ; Gingival Recession/surgery ; Humans ; Male ; Middle Aged ; Minocycline/administration & dosage* ; Ointments ; Periodontal Attachment Loss/drug therapy ; Periodontal Attachment Loss/surgery ; Periodontal Index ; Periodontal Pocket/drug therapy ; Periodontal Pocket/surgery ; Surgical Flaps* ; Treatment Outcome
Keywords
flap surgery ; locally delivered minocycline ; maintenance period ; periodontitis ; repeated application
Abstract
OBJECTIVE: The purpose of this study was to determine the effectiveness of adjunctive application of locally delivered minocycline ointment associated with flap surgery for the treatment of patients with chronic severe periodontitis. MATERIAL AND METHODS: Twenty patients with chronic severe periodontitis were treated in a split-mouth study to either adjunctive application of locally delivered minocycline ointment in association with flap surgery (FM) or flap surgery only (FO); additional minocycline application was performed at 3 months post operation. Clinical evaluation of the plaque index, probing depth (PD), bleeding on probing (BOP), gingival recession, and clinical attachment level (CAL) was conducted at baseline and at 3 and 6 months after treatment. RESULTS: Clinical evaluations revealed that although both sites exhibited clinical improvement, there was a statistically significant reduction in PD (3.34 ± 0.03 mm) and BOP (78.01 ± 11.42%), and a significant gain of CAL (1.88 ± 0.21 mm) at the FM site compared with the FO site (reduction of PD and BOP: 2.62 ± 0.06 mm, 50.33 ± 15.01%, and gain of CAL: 1.55 ± 0.13 mm) at 6 months post operation (p < 0.05). CONCLUSION: Adjunctive application of locally delivered minocycline may be beneficial to the surgical treatment protocol of chronic severe periodontitis.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2012.01908.x/abstract
DOI
22691058
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Park, Jung Chul(박정철)
Cho, Kyoo Sung(조규성) ORCID logo https://orcid.org/0000-0002-6777-5287
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90709
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