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Maturation of alveolar bone following implantation of an rhGDF-5/PLGA composite into 1-wall intra-bony defects in dogs: 24-week histometric observations. : 24-week histometric observations

Authors
 Jung-Chul Park  ;  Ulf M. E. Wikesjö  ;  Ki-Tae Koo  ;  Jung-Seok Lee  ;  Yong-Tae Kim  ;  Susanne D. Pippig  ;  Patrizia Bastone  ;  Chang-Sung Kim  ;  Chong-Kwan Kim 
Citation
 JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.39(6) : 565-573, 2012 
Journal Title
 JOURNAL OF CLINICAL PERIODONTOLOGY 
ISSN
 0303-6979 
Issue Date
2012
MeSH
Absorbable Implants ; Alveolar Bone Loss/drug therapy ; Alveolar Bone Loss/physiopathology* ; Alveolar Process/drug effects ; Alveolar Process/physiology ; Alveolar Process/surgery* ; Animals ; Bone Regeneration/drug effects* ; Dogs ; Drug Carriers ; Growth Differentiation Factor 5/pharmacology* ; Growth Differentiation Factor 5/therapeutic use ; Male ; Mandibular Diseases/drug therapy ; Mandibular Diseases/physiopathology ; Polyesters/pharmacology* ; Random Allocation ; Recombinant Proteins/pharmacology
Keywords
dog ; periodontal regeneration ; PLGA ; rhGDF-5 ; tissue engineering
Abstract
OBJECTIVE: The aim of this study was to evaluate long-term (24 weeks) alveolar bone maturation following surgical application of recombinant human growth/differentiation factor-5 (rhGDF-5) in an injectable poly-lactide-co-glycolide-acid (PLGA) composite carrier using an established periodontal defect model. METHODS: Routine, bilateral, 4 × 5 mm (width × depth), 1-wall, critical-size, intra-bony periodontal defects were surgically created at the 2nd and 4th mandibular premolar teeth in 10 Beagle dogs. The animals were randomized to receive (split-mouth design; defect sites in the same jaw quadrant getting the same treatment) rhGDF-5/PLGA high dose (188 μg/defect) versus sham-surgery control (5 animals), and rhGDF-5/PLGA low dose (37 μg/defect) versus carrier control (5 animals). The animals were euthanized for histometric analysis following a 24-week healing interval. RESULTS: Clinical healing was uneventful. The rhGDF-5 high dose significantly increased bone formation compared with controls in terms of bone area (p < 0.05), and a high degree of bone maturation was observed in the rhGDF-5/PLGA high dose group. Root resorption/ankylosis or other aberrant healing events were not observed. CONCLUSION: The rhGDF-5/PLGA appears to support alveolar bone healing/regeneration and the rhGDF-5/PLGA high dose uniquely increased maturation of the regenerated bone.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2012.01868.x/abstract
DOI
22486310
Appears in Collections:
5. Research Institutes (연구소) > Research Center for Orofacial Hard Tissue Regeneration (구강악안면경조직재생연구센터) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chong Kwan(김종관)
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Park, Jung Chul(박정철)
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90707
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