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Maturation of alveolar bone following implantation of an rhGDF-5/PLGA composite into 1-wall intra-bony defects in dogs: 24-week histometric observations. : 24-week histometric observations
DC Field | Value | Language |
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dc.contributor.author | 이중석 | - |
dc.contributor.author | 김종관 | - |
dc.contributor.author | 김창성 | - |
dc.contributor.author | 박정철 | - |
dc.date.accessioned | 2014-12-19T17:03:48Z | - |
dc.date.available | 2014-12-19T17:03:48Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0303-6979 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90707 | - |
dc.description.abstract | OBJECTIVE: The aim of this study was to evaluate long-term (24 weeks) alveolar bone maturation following surgical application of recombinant human growth/differentiation factor-5 (rhGDF-5) in an injectable poly-lactide-co-glycolide-acid (PLGA) composite carrier using an established periodontal defect model. METHODS: Routine, bilateral, 4 × 5 mm (width × depth), 1-wall, critical-size, intra-bony periodontal defects were surgically created at the 2nd and 4th mandibular premolar teeth in 10 Beagle dogs. The animals were randomized to receive (split-mouth design; defect sites in the same jaw quadrant getting the same treatment) rhGDF-5/PLGA high dose (188 μg/defect) versus sham-surgery control (5 animals), and rhGDF-5/PLGA low dose (37 μg/defect) versus carrier control (5 animals). The animals were euthanized for histometric analysis following a 24-week healing interval. RESULTS: Clinical healing was uneventful. The rhGDF-5 high dose significantly increased bone formation compared with controls in terms of bone area (p < 0.05), and a high degree of bone maturation was observed in the rhGDF-5/PLGA high dose group. Root resorption/ankylosis or other aberrant healing events were not observed. CONCLUSION: The rhGDF-5/PLGA appears to support alveolar bone healing/regeneration and the rhGDF-5/PLGA high dose uniquely increased maturation of the regenerated bone. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PERIODONTOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Absorbable Implants | - |
dc.subject.MESH | Alveolar Bone Loss/drug therapy | - |
dc.subject.MESH | Alveolar Bone Loss/physiopathology* | - |
dc.subject.MESH | Alveolar Process/drug effects | - |
dc.subject.MESH | Alveolar Process/physiology | - |
dc.subject.MESH | Alveolar Process/surgery* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bone Regeneration/drug effects* | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Drug Carriers | - |
dc.subject.MESH | Growth Differentiation Factor 5/pharmacology* | - |
dc.subject.MESH | Growth Differentiation Factor 5/therapeutic use | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mandibular Diseases/drug therapy | - |
dc.subject.MESH | Mandibular Diseases/physiopathology | - |
dc.subject.MESH | Polyesters/pharmacology* | - |
dc.subject.MESH | Random Allocation | - |
dc.subject.MESH | Recombinant Proteins/pharmacology | - |
dc.title | Maturation of alveolar bone following implantation of an rhGDF-5/PLGA composite into 1-wall intra-bony defects in dogs: 24-week histometric observations. : 24-week histometric observations | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Department of Periodontology, Research Center for Orofacial Hard Tissue Regeneration (구강악안면경조직재생연구센터) | - |
dc.contributor.googleauthor | Jung-Chul Park | - |
dc.contributor.googleauthor | Ulf M. E. Wikesjö | - |
dc.contributor.googleauthor | Ki-Tae Koo | - |
dc.contributor.googleauthor | Jung-Seok Lee | - |
dc.contributor.googleauthor | Yong-Tae Kim | - |
dc.contributor.googleauthor | Susanne D. Pippig | - |
dc.contributor.googleauthor | Patrizia Bastone | - |
dc.contributor.googleauthor | Chang-Sung Kim | - |
dc.contributor.googleauthor | Chong-Kwan Kim | - |
dc.identifier.doi | 22486310 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01041 | - |
dc.contributor.localId | A01653 | - |
dc.contributor.localId | A00914 | - |
dc.contributor.localId | A03185 | - |
dc.relation.journalcode | J01337 | - |
dc.identifier.eissn | 1600-051X | - |
dc.identifier.pmid | 22486310 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2012.01868.x/abstract | - |
dc.subject.keyword | dog | - |
dc.subject.keyword | periodontal regeneration | - |
dc.subject.keyword | PLGA | - |
dc.subject.keyword | rhGDF-5 | - |
dc.subject.keyword | tissue engineering | - |
dc.contributor.alternativeName | Lee, Jung Seok | - |
dc.contributor.alternativeName | Kim, Chong Kwan | - |
dc.contributor.alternativeName | Kim, Chang Sung | - |
dc.contributor.alternativeName | Park, Jung Chul | - |
dc.contributor.affiliatedAuthor | Kim, Chang Sung | - |
dc.contributor.affiliatedAuthor | Park, Jung Chul | - |
dc.contributor.affiliatedAuthor | Kim, Chong Kwan | - |
dc.contributor.affiliatedAuthor | Lee, Jung Seok | - |
dc.citation.volume | 39 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 565 | - |
dc.citation.endPage | 573 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.39(6) : 565-573, 2012 | - |
dc.identifier.rimsid | 33483 | - |
dc.type.rims | ART | - |
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