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Comparative evaluation of three calcium phosphate synthetic block bone graft materials for bone regeneration in rabbit calvaria

Authors
 Ji-Wan Hwang  ;  Jae-Sub Park  ;  Jung-Seok Lee  ;  Ui-Won Jung  ;  Chang-Sung Kim  ;  Kyoo-Sung Cho  ;  Yong-Keun Lee  ;  Seong-Ho Choi 
Citation
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol.100(8) : 2044-2052, 2012 
Journal Title
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 
ISSN
 1552-4973 
Issue Date
2012
MeSH
Animals ; Bone Regeneration* ; Bone Substitutes/chemistry ; Bone Substitutes/pharmacology* ; Calcium Phosphates/chemistry ; Calcium Phosphates/pharmacology* ; Durapatite/chemistry ; Durapatite/pharmacology* ; Humans ; Hydroxyapatites/chemistry ; Hydroxyapatites/pharmacology* ; Male ; Materials Testing/methods ; Rabbits ; Skull ; Skull Fractures/therapy* ; Time Factors
Keywords
bone regeneration ; biphasic calcium phosphate ; hydroxyapatite ; beta-tricalcium phosphate ; rabbit calvaria
Abstract
Various synthetic materials were developed to be used for implant dentistry and periodontal treatments. Among the various synthetic bone substitutes, calcium phosphate ceramics have been extensively investigated because their mineral chemistry resembles that of human bone. We evaluated the regeneration of three calcium phosphate synthetic block bone grafts in rabbit calvarial noncritical size defects. Four 8-mm-diameter defects were created in each rabbit (N = 10). Three defects, hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), and biphasic calcium phosphate (BCP), were randomly filled with one of three fabricated synthetic block bone graft materials. The fourth defect was filled with blood clots. Specimens were harvested at 4 and 8 weeks postsurgery. Histological and histometrical findings indicated that all three calcium phosphate block bone graft materials were able to maintain space significantly better than the control group at both 4 and 8 weeks. In the BCP group, the amount of newly formed bone was increased more than for the other groups. Additionally, β-TCP showed a large resorption of graft materials after 4 weeks postsurgery, while there were only small resorption for HA and BCP.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jbm.b.32768/abstract
DOI
22865716
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Sung(김창성) ORCID logo https://orcid.org/0000-0003-3902-1071
Lee, Yong Keun(이용근)
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90631
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