3 123

Cited 0 times in

A nanosized delivery system of superparamagnetic iron oxide for tumor MR imaging.

Authors
 Eun Seong Lee  ;  Chaemin Lim  ;  Ho-Taek Song  ;  Jeong Min Yun  ;  Kyung Soo Lee  ;  Beom-Jin Lee  ;  Yu Seok Youn  ;  Young Taik Oh  ;  Kyung Teak Oh 
Citation
 INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol.439(1-2) : 342-348, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF PHARMACEUTICS 
ISSN
 0378-5173 
Issue Date
2012
MeSH
Animals ; Cell Line, Tumor ; Contrast Media*/administration & dosage ; Contrast Media*/chemistry ; Female ; Humans ; Magnetic Resonance Imaging ; Magnetite Nanoparticles*/administration & dosage ; Magnetite Nanoparticles*/chemistry ; Mice ; Mice, Nude ; Micelles ; Neoplasms/diagnosis* ; Polyethylene Glycols/chemistry ; Xenograft Model Antitumor Assays
Keywords
Polymeric micelle ; Superparamagnetic iron oxide (SPIO) ; Hyperspectrum ; T2 relaxivity coefficients ; Animal imaging
Abstract
Superparamagnetic iron oxide (SPIO) nanoparticles have been intensively investigated as MRI probes due to the noninvasive detection of in vivo pathological changes. In the study, a nanosized system for SPIO delivery to a tumor was prepared to overcome the common challenges of SPIO nanoparticles such as insufficient uptake of SPIO by specific cells due to instability, short half-life by macrophage, and low efficiency of internalization. SPIO with ca. 6 nm sizes as a MRI probe and PLA-PEG (5K-2K) as a biocompatible stable system were prepared. The hydrophobic modified SPIO were loaded into the core of micelles and showed a stable dispersion with 140-170 nm particle sizes. The SPIO loading micelles showed higher relaxivity coefficients and increases of T(2) relaxation in vivo MR imaging. This SPIO delivery system with high stability and sensitivity can be a promising imaging formulation as MRI T(2) probes for tumor detection.
Full Text
http://www.sciencedirect.com/science/article/pii/S0378517312008629
DOI
22959991
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90519
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse