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A nanosized delivery system of superparamagnetic iron oxide for tumor MR imaging.

DC FieldValueLanguage
dc.contributor.author송호택-
dc.contributor.author오영택-
dc.date.accessioned2014-12-19T16:57:44Z-
dc.date.available2014-12-19T16:57:44Z-
dc.date.issued2012-
dc.identifier.issn0378-5173-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90519-
dc.description.abstractSuperparamagnetic iron oxide (SPIO) nanoparticles have been intensively investigated as MRI probes due to the noninvasive detection of in vivo pathological changes. In the study, a nanosized system for SPIO delivery to a tumor was prepared to overcome the common challenges of SPIO nanoparticles such as insufficient uptake of SPIO by specific cells due to instability, short half-life by macrophage, and low efficiency of internalization. SPIO with ca. 6 nm sizes as a MRI probe and PLA-PEG (5K-2K) as a biocompatible stable system were prepared. The hydrophobic modified SPIO were loaded into the core of micelles and showed a stable dispersion with 140-170 nm particle sizes. The SPIO loading micelles showed higher relaxivity coefficients and increases of T(2) relaxation in vivo MR imaging. This SPIO delivery system with high stability and sensitivity can be a promising imaging formulation as MRI T(2) probes for tumor detection.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF PHARMACEUTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHContrast Media*/administration & dosage-
dc.subject.MESHContrast Media*/chemistry-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMagnetite Nanoparticles*/administration & dosage-
dc.subject.MESHMagnetite Nanoparticles*/chemistry-
dc.subject.MESHMice-
dc.subject.MESHMice, Nude-
dc.subject.MESHMicelles-
dc.subject.MESHNeoplasms/diagnosis*-
dc.subject.MESHPolyethylene Glycols/chemistry-
dc.subject.MESHXenograft Model Antitumor Assays-
dc.titleA nanosized delivery system of superparamagnetic iron oxide for tumor MR imaging.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorEun Seong Lee-
dc.contributor.googleauthorChaemin Lim-
dc.contributor.googleauthorHo-Taek Song-
dc.contributor.googleauthorJeong Min Yun-
dc.contributor.googleauthorKyung Soo Lee-
dc.contributor.googleauthorBeom-Jin Lee-
dc.contributor.googleauthorYu Seok Youn-
dc.contributor.googleauthorYoung Taik Oh-
dc.contributor.googleauthorKyung Teak Oh-
dc.identifier.doi22959991-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02080-
dc.contributor.localIdA02390-
dc.relation.journalcodeJ01150-
dc.identifier.eissn1873-3476-
dc.identifier.pmid22959991-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0378517312008629-
dc.subject.keywordPolymeric micelle-
dc.subject.keywordSuperparamagnetic iron oxide (SPIO)-
dc.subject.keywordHyperspectrum-
dc.subject.keywordT2 relaxivity coefficients-
dc.subject.keywordAnimal imaging-
dc.contributor.alternativeNameSong, Ho Taek-
dc.contributor.alternativeNameOh, Young Taik-
dc.contributor.affiliatedAuthorSong, Ho Taek-
dc.contributor.affiliatedAuthorOh, Young Taik-
dc.citation.volume439-
dc.citation.number1-2-
dc.citation.startPage342-
dc.citation.endPage348-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol.439(1-2) : 342-348, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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