Cited 21 times in
A nanosized delivery system of superparamagnetic iron oxide for tumor MR imaging
DC Field | Value | Language |
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dc.contributor.author | 송호택 | - |
dc.contributor.author | 오영택 | - |
dc.date.accessioned | 2014-12-19T16:57:44Z | - |
dc.date.available | 2014-12-19T16:57:44Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90519 | - |
dc.description.abstract | Superparamagnetic iron oxide (SPIO) nanoparticles have been intensively investigated as MRI probes due to the noninvasive detection of in vivo pathological changes. In the study, a nanosized system for SPIO delivery to a tumor was prepared to overcome the common challenges of SPIO nanoparticles such as insufficient uptake of SPIO by specific cells due to instability, short half-life by macrophage, and low efficiency of internalization. SPIO with ca. 6 nm sizes as a MRI probe and PLA-PEG (5K-2K) as a biocompatible stable system were prepared. The hydrophobic modified SPIO were loaded into the core of micelles and showed a stable dispersion with 140-170 nm particle sizes. The SPIO loading micelles showed higher relaxivity coefficients and increases of T(2) relaxation in vivo MR imaging. This SPIO delivery system with high stability and sensitivity can be a promising imaging formulation as MRI T(2) probes for tumor detection. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Contrast Media*/administration & dosage | - |
dc.subject.MESH | Contrast Media*/chemistry | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Magnetite Nanoparticles*/administration & dosage | - |
dc.subject.MESH | Magnetite Nanoparticles*/chemistry | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Micelles | - |
dc.subject.MESH | Neoplasms/diagnosis* | - |
dc.subject.MESH | Polyethylene Glycols/chemistry | - |
dc.subject.MESH | Xenograft Model Antitumor Assays | - |
dc.title | A nanosized delivery system of superparamagnetic iron oxide for tumor MR imaging | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Eun Seong Lee | - |
dc.contributor.googleauthor | Chaemin Lim | - |
dc.contributor.googleauthor | Ho-Taek Song | - |
dc.contributor.googleauthor | Jeong Min Yun | - |
dc.contributor.googleauthor | Kyung Soo Lee | - |
dc.contributor.googleauthor | Beom-Jin Lee | - |
dc.contributor.googleauthor | Yu Seok Youn | - |
dc.contributor.googleauthor | Young Taik Oh | - |
dc.contributor.googleauthor | Kyung Teak Oh | - |
dc.identifier.doi | 10.1016/j.ijpharm.2012.08.054 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02080 | - |
dc.contributor.localId | A02390 | - |
dc.relation.journalcode | J01150 | - |
dc.identifier.eissn | 1873-3476 | - |
dc.identifier.pmid | 22959991 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0378517312008629 | - |
dc.subject.keyword | Polymeric micelle | - |
dc.subject.keyword | Superparamagnetic iron oxide (SPIO) | - |
dc.subject.keyword | Hyperspectrum | - |
dc.subject.keyword | T2 relaxivity coefficients | - |
dc.subject.keyword | Animal imaging | - |
dc.contributor.alternativeName | Song, Ho Taek | - |
dc.contributor.alternativeName | Oh, Young Taik | - |
dc.contributor.affiliatedAuthor | Song, Ho Taek | - |
dc.contributor.affiliatedAuthor | Oh, Young Taik | - |
dc.citation.volume | 439 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 342 | - |
dc.citation.endPage | 348 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol.439(1-2) : 342-348, 2012 | - |
dc.identifier.rimsid | 32814 | - |
dc.type.rims | ART | - |
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