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Multifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy.

Authors
 Dong Jin Lee  ;  Ga Young Park  ;  Kyung Taek Oh  ;  Nam Muk Oh  ;  Dong Sup Kwag  ;  Yu Seok Youn  ;  Young Taik Oh  ;  Jin woo Park  ;  Eun Seong Lee 
Citation
 INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol.434(1-2) : 257-263, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF PHARMACEUTICS 
ISSN
 0378-5173 
Issue Date
2012
MeSH
Animals ; Cell Line, Tumor ; Dextrans ; Female ; Ferric Compounds ; Humans ; KB Cells ; Lactic Acid/chemistry* ; Luminescent Measurements/methods ; Magnetic Resonance Imaging/methods* ; Magnetite Nanoparticles ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nanoparticles* ; Neoplasms/diagnosis ; Neoplasms/pathology ; Neoplasms/therapy ; Photochemotherapy/methods* ; Photosensitizing Agents/administration & dosage ; Photosensitizing Agents/chemistry ; Polyethylene Glycols/chemistry ; Polyglactin 910/chemistry ; Polyglycolic Acid/chemistry* ; Porphyrins
Keywords
Poly (lactide-co-glycolide) ; Fe3O4 ; Photodynamic therapy (PDT) ; Magnetic resonance imaging (MRI)
Abstract
Poly (lactide-co-glycolide) (PLGA) coupled with methoxy poly (ethylene glycol) (mPEG) or chlorin e6 (Ce6) was synthesized using the Steglich esterification method. PLGA-linked mPEG (PLGA-mPEG), PLGA-linked Ce6 (PLGA-Ce6), and Fe(3)O(4) were utilized to constitute multifunctional PLGA nanoparticles (∼160 nm) via the multi-emulsion W(1)/O/W(2) (water-in-oil-in-water) method. The photo-sensitizing properties of Ce6 molecules anchored to PLGA nanoparticles enabled in vivo luminescence imaging and photodynamic therapy for the tumor site. The encapsulation of Fe(3)O(4) allowed high contrast magnetic resonance (MR) imaging of the tumor in vivo. Overall, PLGA nanoparticles resulted in a significant tumor volume regression for the light-illuminated KB tumor in vivo and enhanced the contrast at the tumor region, compared to that of Feridex(®) (commercial contrast agent).
Full Text
http://www.sciencedirect.com/science/article/pii/S0378517312005881
DOI
22664459
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90518
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