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Multifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy.
DC Field | Value | Language |
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dc.contributor.author | 오영택 | - |
dc.date.accessioned | 2014-12-19T16:57:42Z | - |
dc.date.available | 2014-12-19T16:57:42Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90518 | - |
dc.description.abstract | Poly (lactide-co-glycolide) (PLGA) coupled with methoxy poly (ethylene glycol) (mPEG) or chlorin e6 (Ce6) was synthesized using the Steglich esterification method. PLGA-linked mPEG (PLGA-mPEG), PLGA-linked Ce6 (PLGA-Ce6), and Fe(3)O(4) were utilized to constitute multifunctional PLGA nanoparticles (∼160 nm) via the multi-emulsion W(1)/O/W(2) (water-in-oil-in-water) method. The photo-sensitizing properties of Ce6 molecules anchored to PLGA nanoparticles enabled in vivo luminescence imaging and photodynamic therapy for the tumor site. The encapsulation of Fe(3)O(4) allowed high contrast magnetic resonance (MR) imaging of the tumor in vivo. Overall, PLGA nanoparticles resulted in a significant tumor volume regression for the light-illuminated KB tumor in vivo and enhanced the contrast at the tumor region, compared to that of Feridex(®) (commercial contrast agent). | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Dextrans | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Ferric Compounds | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | KB Cells | - |
dc.subject.MESH | Lactic Acid/chemistry* | - |
dc.subject.MESH | Luminescent Measurements/methods | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Magnetite Nanoparticles | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Nanoparticles* | - |
dc.subject.MESH | Neoplasms/diagnosis | - |
dc.subject.MESH | Neoplasms/pathology | - |
dc.subject.MESH | Neoplasms/therapy | - |
dc.subject.MESH | Photochemotherapy/methods* | - |
dc.subject.MESH | Photosensitizing Agents/administration & dosage | - |
dc.subject.MESH | Photosensitizing Agents/chemistry | - |
dc.subject.MESH | Polyethylene Glycols/chemistry | - |
dc.subject.MESH | Polyglactin 910/chemistry | - |
dc.subject.MESH | Polyglycolic Acid/chemistry* | - |
dc.subject.MESH | Porphyrins | - |
dc.title | Multifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Dong Jin Lee | - |
dc.contributor.googleauthor | Ga Young Park | - |
dc.contributor.googleauthor | Kyung Taek Oh | - |
dc.contributor.googleauthor | Nam Muk Oh | - |
dc.contributor.googleauthor | Dong Sup Kwag | - |
dc.contributor.googleauthor | Yu Seok Youn | - |
dc.contributor.googleauthor | Young Taik Oh | - |
dc.contributor.googleauthor | Jin woo Park | - |
dc.contributor.googleauthor | Eun Seong Lee | - |
dc.identifier.doi | 22664459 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02390 | - |
dc.relation.journalcode | J01150 | - |
dc.identifier.eissn | 1873-3476 | - |
dc.identifier.pmid | 22664459 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0378517312005881 | - |
dc.subject.keyword | Poly (lactide-co-glycolide) | - |
dc.subject.keyword | Fe3O4 | - |
dc.subject.keyword | Photodynamic therapy (PDT) | - |
dc.subject.keyword | Magnetic resonance imaging (MRI) | - |
dc.contributor.alternativeName | Oh, Young Taik | - |
dc.contributor.affiliatedAuthor | Oh, Young Taik | - |
dc.citation.volume | 434 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 257 | - |
dc.citation.endPage | 263 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol.434(1-2) : 257-263, 2012 | - |
dc.identifier.rimsid | 32813 | - |
dc.type.rims | ART | - |
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