3 149

Cited 0 times in

Multifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy.

DC FieldValueLanguage
dc.contributor.author오영택-
dc.date.accessioned2014-12-19T16:57:42Z-
dc.date.available2014-12-19T16:57:42Z-
dc.date.issued2012-
dc.identifier.issn0378-5173-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/90518-
dc.description.abstractPoly (lactide-co-glycolide) (PLGA) coupled with methoxy poly (ethylene glycol) (mPEG) or chlorin e6 (Ce6) was synthesized using the Steglich esterification method. PLGA-linked mPEG (PLGA-mPEG), PLGA-linked Ce6 (PLGA-Ce6), and Fe(3)O(4) were utilized to constitute multifunctional PLGA nanoparticles (∼160 nm) via the multi-emulsion W(1)/O/W(2) (water-in-oil-in-water) method. The photo-sensitizing properties of Ce6 molecules anchored to PLGA nanoparticles enabled in vivo luminescence imaging and photodynamic therapy for the tumor site. The encapsulation of Fe(3)O(4) allowed high contrast magnetic resonance (MR) imaging of the tumor in vivo. Overall, PLGA nanoparticles resulted in a significant tumor volume regression for the light-illuminated KB tumor in vivo and enhanced the contrast at the tumor region, compared to that of Feridex(®) (commercial contrast agent).-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF PHARMACEUTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHDextrans-
dc.subject.MESHFemale-
dc.subject.MESHFerric Compounds-
dc.subject.MESHHumans-
dc.subject.MESHKB Cells-
dc.subject.MESHLactic Acid/chemistry*-
dc.subject.MESHLuminescent Measurements/methods-
dc.subject.MESHMagnetic Resonance Imaging/methods*-
dc.subject.MESHMagnetite Nanoparticles-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred BALB C-
dc.subject.MESHMice, Nude-
dc.subject.MESHNanoparticles*-
dc.subject.MESHNeoplasms/diagnosis-
dc.subject.MESHNeoplasms/pathology-
dc.subject.MESHNeoplasms/therapy-
dc.subject.MESHPhotochemotherapy/methods*-
dc.subject.MESHPhotosensitizing Agents/administration & dosage-
dc.subject.MESHPhotosensitizing Agents/chemistry-
dc.subject.MESHPolyethylene Glycols/chemistry-
dc.subject.MESHPolyglactin 910/chemistry-
dc.subject.MESHPolyglycolic Acid/chemistry*-
dc.subject.MESHPorphyrins-
dc.titleMultifunctional poly (lactide-co-glycolide) nanoparticles for luminescence/magnetic resonance imaging and photodynamic therapy.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorDong Jin Lee-
dc.contributor.googleauthorGa Young Park-
dc.contributor.googleauthorKyung Taek Oh-
dc.contributor.googleauthorNam Muk Oh-
dc.contributor.googleauthorDong Sup Kwag-
dc.contributor.googleauthorYu Seok Youn-
dc.contributor.googleauthorYoung Taik Oh-
dc.contributor.googleauthorJin woo Park-
dc.contributor.googleauthorEun Seong Lee-
dc.identifier.doi22664459-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02390-
dc.relation.journalcodeJ01150-
dc.identifier.eissn1873-3476-
dc.identifier.pmid22664459-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0378517312005881-
dc.subject.keywordPoly (lactide-co-glycolide)-
dc.subject.keywordFe3O4-
dc.subject.keywordPhotodynamic therapy (PDT)-
dc.subject.keywordMagnetic resonance imaging (MRI)-
dc.contributor.alternativeNameOh, Young Taik-
dc.contributor.affiliatedAuthorOh, Young Taik-
dc.citation.volume434-
dc.citation.number1-2-
dc.citation.startPage257-
dc.citation.endPage263-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol.434(1-2) : 257-263, 2012-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.