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Photodynamic therapy using glycol chitosan grafted fullerenes.

Authors
 Dong Sup Kwag  ;  Nam Muk Oh  ;  Young Taik Oh  ;  Kyung Taek Oh  ;  Yu Seok Youn  ;  Eun Seong Lee 
Citation
 INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol.431(1-2) : 204-209, 2012 
Journal Title
 INTERNATIONAL JOURNAL OF PHARMACEUTICS 
ISSN
 0378-5173 
Issue Date
2012
MeSH
Animals ; Cell Line, Tumor ; Chitosan/administration & dosage* ; Female ; Fullerenes/administration & dosage* ; Humans ; Light ; Mice ; Mice, Nude ; Neoplasms/drug therapy* ; Photochemotherapy/methods* ; Photosensitizing Agents/administration & dosage*
Keywords
Fullerene conjugates ; Glycol chitosan ; Photodynamic therapy
Abstract
synthesized in anhydrous benzene/dimethylsulfoxide (DMSO) co-solvent via the chemical conjugation of free amine groups of GC to CC double bonds of C(60). The GC-g-C(60) with 5×10(-4) C(60) molecules per one repeating unit of GC was soluble in water. As C(60) molecules conjugated to GC increased to 0.16 molecules per one repeating unit of GC, GC-g-C(60) started to form supramolecular assemblies (∼30 nm) stabilized in phosphate buffer saline (PBS, 150 mM, pH 7.4). Upon 670 nm light illumination, photo-responsive properties of GC-g-C(60) allowed tremendous singlet oxygen generation in tumor cells for super phototoxicity. GC-g-C(60) also showed highly increased tumor accumulation ability for in vivo tumor of KB tumor-bearing nude mice. It is expected that our GC-g-C(60) conjugate may be a good candidate for in vivo photodynamic therapy in various malignant tumor cells.
Full Text
http://www.sciencedirect.com/science/article/pii/S0378517312003845
DOI
22537808
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/90517
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