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Photodynamic therapy using glycol chitosan grafted fullerenes.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오영택 | - |
dc.date.accessioned | 2014-12-19T16:57:40Z | - |
dc.date.available | 2014-12-19T16:57:40Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/90517 | - |
dc.description.abstract | synthesized in anhydrous benzene/dimethylsulfoxide (DMSO) co-solvent via the chemical conjugation of free amine groups of GC to CC double bonds of C(60). The GC-g-C(60) with 5×10(-4) C(60) molecules per one repeating unit of GC was soluble in water. As C(60) molecules conjugated to GC increased to 0.16 molecules per one repeating unit of GC, GC-g-C(60) started to form supramolecular assemblies (∼30 nm) stabilized in phosphate buffer saline (PBS, 150 mM, pH 7.4). Upon 670 nm light illumination, photo-responsive properties of GC-g-C(60) allowed tremendous singlet oxygen generation in tumor cells for super phototoxicity. GC-g-C(60) also showed highly increased tumor accumulation ability for in vivo tumor of KB tumor-bearing nude mice. It is expected that our GC-g-C(60) conjugate may be a good candidate for in vivo photodynamic therapy in various malignant tumor cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Chitosan/administration & dosage* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fullerenes/administration & dosage* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Light | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Neoplasms/drug therapy* | - |
dc.subject.MESH | Photochemotherapy/methods* | - |
dc.subject.MESH | Photosensitizing Agents/administration & dosage* | - |
dc.title | Photodynamic therapy using glycol chitosan grafted fullerenes. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Dong Sup Kwag | - |
dc.contributor.googleauthor | Nam Muk Oh | - |
dc.contributor.googleauthor | Young Taik Oh | - |
dc.contributor.googleauthor | Kyung Taek Oh | - |
dc.contributor.googleauthor | Yu Seok Youn | - |
dc.contributor.googleauthor | Eun Seong Lee | - |
dc.identifier.doi | 22537808 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02390 | - |
dc.relation.journalcode | J01150 | - |
dc.identifier.eissn | 1873-3476 | - |
dc.identifier.pmid | 22537808 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0378517312003845 | - |
dc.subject.keyword | Fullerene conjugates | - |
dc.subject.keyword | Glycol chitosan | - |
dc.subject.keyword | Photodynamic therapy | - |
dc.contributor.alternativeName | Oh, Young Taik | - |
dc.contributor.affiliatedAuthor | Oh, Young Taik | - |
dc.citation.volume | 431 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 204 | - |
dc.citation.endPage | 209 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, Vol.431(1-2) : 204-209, 2012 | - |
dc.identifier.rimsid | 32812 | - |
dc.type.rims | ART | - |
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